Rupatadine is effective in the treatment of chronic spontaneous urticaria in children aged 2-11 years

by mm-red | Jul 30, 2020

Background: Recommendations in current guidelines for the treatment of chronic spontaneous urticaria (CSU) in infants and children are mostly based on extrapolation of data obtained in adults. This study reports the efficacy and safety of rupatadine, amodern H1and PAF...

Similar Efficacy with Omalizumab in Chronic Idiopathic/Spontaneous Urticaria Despite Different Background Therapy

by mm-red | Jul 29, 2020

Background: Data from the 3 omalizumab pivotal trials inpatients with chronic idiopathic urticaria/chronic spontaneous urticaria (CIU/CSU) represent the largest database of patients reported to date with refractory disease (omalizumab, n[733;placebo, n[242)....

Modern Approaches to the Diagnosis and Treatment of Cold Contact Urticaria

by mm-red | Jun 26, 2020

Cold contact urticaria (CCU) is a common subtype of physical urticaria characterized by itchy wheals and/or angioedema due to skin mast cell activation and the release of proinflammatory mediators after cold exposure. The underlying causes are largely unknown. When...

Treatment strategies in mastocytosis

by mm-red | Jun 26, 2020

Brain histamine H1 receptor occupancy measured by PET after oral administration of levocetirizine, a non-sedating antihistamine

by mm-red | Jun 6, 2020

Objective: Histamine H1 receptor (H1R) antagonists often have sedative side effects, which are caused by the blockade of the neural transmission of the histaminergic neurons. We examined the brain H1R occupancy (H1RO) and the subjective sleepiness of levocetirizine, a...