Autoimmune diseases are linked to type IIb autoimmune chronic spontaneous urticaria

by admin | May 31, 2021

Purpose: Patients with chronic spontaneous urticaria (CSU) have an increased risk for comorbid autoimmune diseases. In this retrospective multicenter study of CSU patients, we evaluated clinical and laboratory features of CSU associated with a higher risk of comorbid...

IgM and IgA in addition to IgG autoantibodies against FceRIa are frequent and associated with disease markers of chronic spontaneous urticaria

by admin | Nov 17, 2020

Background: IgG autoantibodies against the high-affinity IgE receptor, FcɛRIα, contribute the pathogenesis of autoimmune chronic spontaneous urticaria (CSU). However, it is not known whether such patients also exhibit IgM or IgA autoantibod- ies against FcɛRIα. To...

Interleukin-17 is a potential player and treatment target in severe chronic spontaneous urticaria

by admin | Oct 6, 2020

Background: Chronic spontaneous urticaria (CSU) is considered an autoimmune disorder in 50% of cases at least, in which T- and mast cell mediators are considered to be the primary cause of symptoms. However , H1-antihistamines, cyclosporine A, and omalizumab fail to...

Autoimmune chronic spontaneous urticaria: what we know and what we don‘t know

by mm-red | Jun 21, 2020

Chronic spontaneous urticaria (CSU) is a mast cell–driven skin disease characterized by the recurrence of transient wheals, angioedema, or both for more than 6 weeks. Autoimmunity is thought to be one of the most frequent causes of CSU. Type I and II autoimmunity (ie,...

Aktuelle wissenschaftliche Erkenntnisse zur Mastzelle: Bedeutung für die Praxis

by mm-red | Jun 21, 2020