The pharmacological modulation of mast cells and basophils

by admin | Sep 29, 2020

The role of the IL-33/IL-1RL1 axis in mast cell and basophil activation in allergic disorders

by mm-red | Jun 25, 2020

Interleukin-33 (IL-33) is a recently discovered cytokine that belongs to the IL-1 superfamily and acts as an important regulator in several allergic disorders. It is considered to function as an alarmin, or danger cytokine, that is released upon structural cell...

Molecular targets on mast cells and basophils for novel therapies

by mm-red | Jun 25, 2020

Mast cells and basophils (MCs/Bs) play a crucial role in type I allergy, as well as in innate and adaptive immune responses. These cells mediate their actions through soluble mediators, some of which are targeted therapeutically by, for example, H1- and...

Factors responsible for differences between asymptomatic subjects and patients presenting an IgE sensitization to allergens. A GA²LEN project

by mm-red | Jun 18, 2020

Basophilic histamine content and release during venom immunotherapy: insights by flow cytometry

by mm-red | Jun 5, 2020

Background: Despite the efficiency of venom immunotherapy, the effects on basophils and mast cells remain incompletely understood and probably vary according to the treatment phase. Objectives: To study the effect of build-up and maintenance venom immunotherapy on...