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Lower IgA levels in chronic spontaneous urticaria are associated with lower IgE levels and autoimmunity

Lower IgA levels in chronic spontaneous urticaria are associated with lower IgE levels and autoimmunity

by admin | Jun 1, 2021

Background: The pathogenesis of chronic spontaneous urticaria (CSU) is stillinsufficiently understood. Recentfindings suggest that immunoglobulins, in particularIgE but also IgA, play a role in the development of CSU. Objective: Our aim was to assess differences in...
Lower IgA levels in chronic spontaneous urticaria are associated with lower IgE levels and autoimmunity

Differences and similarities in the mechanisms and clinical expression of bradykinin-mediated vs. mast cell-mediated angioedema

by admin | May 31, 2021

Guidelines for the treatment of chronic spontaneous urticaria (CSU) recommend the use of the IgE-targeted biologic omalizumab in patients with antihistamine-refractory disease. The rationale for this is supported by the key role of IgE and its high-affinity receptor,...
Novel aspects of mast cell and basophil function: highlights from the 9th meeting of the European Mast Cell and Basophil Research Network (EMBRN) – a Marcus Wallenberg Symposium

Novel aspects of mast cell and basophil function: highlights from the 9th meeting of the European Mast Cell and Basophil Research Network (EMBRN) – a Marcus Wallenberg Symposium

by admin | Apr 23, 2020

Mast cells and basophils are important members of the immune sys‐tem. Both of these cell types are implicated in allergic responses, being strongly responsive to activation/degranulation through aller‐gen‐induced crosslinking of IgE molecules bound to their...

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