Background: The pathogenesis of chronic spontaneous urticaria (CSU) is stillinsufficiently understood. Recentfindings suggest that immunoglobulins, in particularIgE but also IgA, play a role in the development of CSU. Objective: Our aim was to assess differences in...
Guidelines for the treatment of chronic spontaneous urticaria (CSU) recommend the use of the IgE-targeted biologic omalizumab in patients with antihistamine-refractory disease. The rationale for this is supported by the key role of IgE and its high-affinity receptor,...
Mast cells and basophils are important members of the immune sys‐tem. Both of these cell types are implicated in allergic responses, being strongly responsive to activation/degranulation through aller‐gen‐induced crosslinking of IgE molecules bound to their...
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