The factors influencing the heterogeneous clinical manifestation of hereditary angioedema due to C1-INH deficiency (C1-INH-HAE) represent one of the oldest unsolved problems of the disease. Considering that factor XII (FXII) levels may affect bradykinin production, we...
Background: In view of the large heterogeneity in the clini- cal presentation of hereditary angioedema due to C1 inhibitor deficiency (C1-INH-HAE), great efforts are being made to- wards detecting measurable biological determinants of disease severity that can help to...
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