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A simulated car-driving study on the effects of acute administration of levocetirizine, fexofenadine, and diphenhydramine in healthy Japanese volunteers

A simulated car-driving study on the effects of acute administration of levocetirizine, fexofenadine, and diphenhydramine in healthy Japanese volunteers

by mm-red | Jul 30, 2020

Objective: Antihistamines are often used for treating allergic rhinitis. However, many older antihistamines cause sedative side effects. The sedative effects of antihistamines on car-driving have been investigated. This has not been investigated for levocetirizine, a...
A simulated car-driving study on the effects of acute administration of levocetirizine, fexofenadine, and diphenhydramine in healthy Japanese volunteers

H1-antihistamines and urticaria: how can we predict the best drug for our patient?

by mm-red | Jun 26, 2020

Urticaria, and especially chronic spontaneous urticaria (CSU), is a difficult condition to treat. Consequently, clinicians need to use the best H1-antihistamines currently available and the pharmaceutical industries need to keep developing H1-antihistamines that are...
A simulated car-driving study on the effects of acute administration of levocetirizine, fexofenadine, and diphenhydramine in healthy Japanese volunteers

The inhibition by levocetirizine and fexofenadine of the histamine-induced wheal and flare response in healthy Caucasian and Japanese volunteers

by mm-red | Jun 5, 2020

This randomized, double-blind, placebo-controlled cross- over study compared inhibition by one 5 mg dose of levocetirizine with two 60 mg doses of fexofenadine se- parated by 12 h of histamine-induced wheal and are responses in 9 Caucasian and 9 Japanese healthy male...

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