Chronic cold urticaria (ColdU) is a rare disease charac-terized by mast cell-mediated wheals and angioedema following cold exposure. Second-generation H1-anti-histamines, such as rupatadine, are the recommended first-line therapy. As of yet, the effects of rupatadine...
In a review of rupatadine published in 2008, the primary focus was on its role as an antihistamine, with a thorough evaluation of its pharmacology and inter- action with histamine H1-receptors. At the time, however, evidence was already emerging of a broader mechanism...
Background: Cold contact urticaria (CCU) is characterized by itchy wheal and flare responses due to the release of histamine and other pro-inflammatory media- tors after exposure to cold. The treatment of choice is nonsedating antihista- mines, dosages of which may be...
Background: Patients with chronic idiopathic urticaria/ chronic spontaneous urticaria (CIU/CSU) often continue to experience symptoms despite receiving standard-of-care therapy with H1-antihistamines along with 1 or more add-on therapies. Objectives: We sought to...
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