Flare size but not intensity reflects histamine-induced itch

Flare size but not intensity reflects histamine-induced itch

Introduction: Flare reactions arise due to the release of vasodilators from sensory nerves caused by antidromic transmission of action potentials after the induction of itch. Objective: We investigated the link between flare and itch using 3 models of itch. Methods:...
Flare size but not intensity reflects histamine-induced itch

Urticaria

Urticaria is a heterogeneous group of diseases. Wheals and angioedema are the signature signs and itch is the key symptom. Most cases of urticaria resolve within days. Those that do not tend to be of long duration and associated with severely impaired quality of life....
Flare size but not intensity reflects histamine-induced itch

Skin provocation tests may help to diagnose atopic dermatitis

Background: Atopic dermatitis (AD) is a common skin disorder. Its diagnosis relieson clinical judgment. Mild and untypical manifestations may cause diagnostic difficulties. Biomarkers for the differential diagnostic workup of AD are needed. Objective: To test whether...
Flare size but not intensity reflects histamine-induced itch

Histamine and Antihistamines in Atopic Dermatitis

Itching (pruritus) is perhaps the most common symptom associated with numerous skin diseases and can be a lead symptom of extracutaneous disease (e.g., malignancy, infection, metabolic dis‑ orders). Also in atopic dermatitis itching sensations constitute one of the...
Flare size but not intensity reflects histamine-induced itch

Mast cells: makers and breakers of allergic inflammation

Purpose of review: Recent findings have developed, changed, challenged and extended the established view of mast cell biology and of their role in inflammation. The purpose of this review is to present and discuss recent research in this area relating to allergic...