Mas-related G protein-coupled receptor X2 and its activators in dermatologic allergies

Flare size but not intensity reflects histamine-induced itch

by | Nov 14, 2020

Introduction: Flare reactions arise due to the release of vasodilators from sensory nerves caused by antidromic transmission of action potentials after the induction of itch. Objective: We investigated the link between flare and itch using 3 models of itch. Methods:...
Mas-related G protein-coupled receptor X2 and its activators in dermatologic allergies

Urticaria

by | Aug 2, 2020

Urticaria is a heterogeneous group of diseases. Wheals and angioedema are the signature signs and itch is the key symptom. Most cases of urticaria resolve within days. Those that do not tend to be of long duration and associated with severely impaired quality of life....
Mas-related G protein-coupled receptor X2 and its activators in dermatologic allergies

Anti-pruritic effect of sertaconazole 2% cream in atopic dermatitis subjects: a prospective, randomized, double-blind, vehicle-controlled, multi-centre clinical trial of efficacy, safety and local tolerability

by | Jul 30, 2020

This study was a prospective, parallel-group, randomi-zed, double-blind, vehicle-controlled, multi-centre clini-cal trial to compare the efficacy of topical sertaconazole 2% cream with vehicle in reducing chronic pruritus in subjects with atopic dermatitis, and to...