Purpose of review: Recent findings have developed, changed, challenged and extended the established view of mast cell biology and of their role in inflammation. The purpose of this review is to present and discuss recent research in this area relating to allergic...
Background: Mastocytosis is frequently associated with mast cell-mediated symp- toms which require relieving medication. While second generation antihistamines (sgAHs) are the first line therapeutic strategy to treat mast cell mediator-related symptoms, controlled...
Background: Platelet-activating factor (PAF) causes wheal and flare responses which are abrogated by H1-antihistamines giving rise to the hypothesis that PAF- induced wheal development is secondary to histamine release from dermal mast cells. But is this hypothesis...
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