Mas-related G protein-coupled receptor X2 and its activators in dermatologic allergies

Flare size but not intensity reflects histamine-induced itch

Introduction: Flare reactions arise due to the release of vasodilators from sensory nerves caused by antidromic transmission of action potentials after the induction of itch. Objective: We investigated the link between flare and itch using 3 models of itch. Methods:...
Mas-related G protein-coupled receptor X2 and its activators in dermatologic allergies

Anti-pruritic effect of sertaconazole 2% cream in atopic dermatitis subjects: a prospective, randomized, double-blind, vehicle-controlled, multi-centre clinical trial of efficacy, safety and local tolerability

This study was a prospective, parallel-group, randomi-zed, double-blind, vehicle-controlled, multi-centre clini-cal trial to compare the efficacy of topical sertaconazole 2% cream with vehicle in reducing chronic pruritus in subjects with atopic dermatitis, and to...
Mas-related G protein-coupled receptor X2 and its activators in dermatologic allergies

Skin provocation tests may help to diagnose atopic dermatitis

Background: Atopic dermatitis (AD) is a common skin disorder. Its diagnosis relieson clinical judgment. Mild and untypical manifestations may cause diagnostic difficulties. Biomarkers for the differential diagnostic workup of AD are needed. Objective: To test whether...