Background: Patients with chronic spontaneous urticaria (CSU), an autoimmune disorder, show increased skin expression of IL-17A and can benefit from treatment with the anti-IL-17A biologic secukinumab. The mechanisms that drive IL-17A expression in CSU are currently...
Cutaneous leishmanias is (CL) patients coinfected with HIV are known to show a more severe, prolonged course of disease;the immunological basis is not known. We now assessed clinical features, sera and skin biopsies of HIV+and HIV-patients with CLto identify drivers...
Mast cells (MCs) are found abundantly in the brain and the meninges and play a complex role in neuroinflammatory diseases, such as stroke and multiple sclerosis. Here, we show that MC-deficient KitW/KitW-v mice display increased neurodegeneration in the lesion area...
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