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The expression of IL-17, in chronic spontaneous urticaria is linked to semaphorin5A

The expression of IL-17, in chronic spontaneous urticaria is linked to semaphorin5A

by admin | May 31, 2021

Background: Patients with chronic spontaneous urticaria (CSU), an autoimmune disorder, show increased skin expression of IL-17A and can benefit from treatment with the anti-IL-17A biologic secukinumab. The mechanisms that drive IL-17A expression in CSU are currently...
Impaired T-cell-dependent protection against Leishmania major infection in HIV-positive patients is associated with worsened disease outcome

Impaired T-cell-dependent protection against Leishmania major infection in HIV-positive patients is associated with worsened disease outcome

by mm-red | Jul 28, 2020

Cutaneous leishmanias is (CL) patients coinfected with HIV are known to show a more severe, prolonged course of disease;the immunological basis is not known. We now assessed clinical features, sera and skin biopsies of HIV+and HIV-patients with CLto identify drivers...
Impaired T-cell-dependent protection against Leishmania major infection in HIV-positive patients is associated with worsened disease outcome

Mast cells protect from post-traumatic brain inflammation by the mast cell-specific chymase mouse mast cell protease-4

by mm-red | Jun 5, 2020

Mast cells (MCs) are found abundantly in the brain and the meninges and play a complex role in neuroinflammatory diseases, such as stroke and multiple sclerosis. Here, we show that MC-deficient KitW/KitW-v mice display increased neurodegeneration in the lesion area...

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