Background: The efficacy of omalizumab (anti-IgE) and increased IgE levels in patients with chronic spontaneous urticaria (CSU) suggest autoallergic mechanisms. Objective: We sought to identify autoallergic targets of IgE in patients with CSU. Methods: Serum samples...
This randomized, double-blind, placebo-controlled cross- over study compared inhibition by one 5 mg dose of levocetirizine with two 60 mg doses of fexofenadine se- parated by 12 h of histamine-induced wheal and are responses in 9 Caucasian and 9 Japanese healthy male...
Background: Platelet-activating factor (PAF) causes wheal and flare responses which are abrogated by H1-antihistamines giving rise to the hypothesis that PAF- induced wheal development is secondary to histamine release from dermal mast cells. But is this hypothesis...
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