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Acquired cold urticaria symptoms can be safely prevented by ebastine
| Filename | 57. Magerl et al.Acquired cold urt. Ebastine.Allergy 2007.pdf |
| Filesize | 148,99 kB |
| Version | o.057 |
| Date added | Mai 26, 2020 |
| Downloaded | 0 times |
| Category | Original Work |
| Authors | Magerl, M., Schmolke, J, Siebenhaar, F., Zuberbier, T., Metz, M., and Maurer, M. |
| Citation | Magerl, M., Schmolke, J, Siebenhaar, F., Zuberbier, T., Metz, M., and Maurer, M.: Acquired cold urticaria symptoms can be safely prevented by Ebastine. Allergy 2007: 62; 1465-1468. IF: 5.01 |
| Corresponding authors | Maurer, M. |
| DocNum | O.57 |
| DocType | |
| Edition; Page | 62; 1465-1468 |
| IF | 5.01 |
| Publisher | Allergy |
| ReleaseDate | 2007 |
Background: Acquired cold urticaria (ACU) is a skin condition, in which exposure to cold results in wheals and itching and sometimes general systemic complications. It has a profound impact on patient quality of life. Secondgeneration antihistamines are recommended as the first-line treatment, but to date only a few have been scientifically tested for this condition.
Aim: To assess the safety and efficacy of ebastine in preventing ACU symptoms.
Methods: Twenty-two adult ACU patients participated in a double-blind crossover trial of 20 mg ebastine. The safety of ebastine was sensitively assessedwith a psychometric battery testing cognitive performance and mood. After cold challenge, wheal and erythema were assessed by the investigator and the intensities of pruritus and burning were rated by the subject.
Results: Ebastine had no negative impact on any of the parameters of cognitive performance or mood. It dramatically reduced the number of patients who experienced wheals, pruritus, and burning after challenge.
Conclusion: Ebastine is safe and effective in preventing the symptoms of ACU.
(Last update: 12.2023)
| Number of original publications in peer-reviewed journals: | 580 |
| Number of reviews in peer-reviewed journals: | 210 |
| Number of publications (original work and reviews) in peer-reviewed journals: | 790 |
| Cumulative IF for original publications in peer-reviewed journals: | 4196.39 |
| Cumulative IF for reviews in peer-reviewed journals: | 1409.32 |
| Cumulative IF of publications (original work & reviews) in peer-reviewed journals: | 5605.71 |
| Total number of citations: 36,836, h-index: 99 (Web of Science December 2023) | 36836 |
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