Veröffentlichungen
Originalarbeiten, Bücher, Buchkapitel und Übersichtsartikel von Prof. Marcus Maurer
Verwendung: Beginnen Sie mit einer Übersicht über alle Publikationen. Verwenden Sie Tag-Links, um markierte Dokumente aufzulisten oder eine ganze Kategorie aufzulisten, z.B. Original Work (Originalarbeiten), Books (Bücher), Book Chapters (Buchkapitel), Reviews (Übersichtsartikel). Wenn Sie wissen, was Sie suchen, dann geben Sie diesen Begriff in das Suchfeld ein.
Development, validation, and initial results of the angioedema activity score
Filename | 170. Weller et al.,Dev.valid.and initial results of AAS,ALLERGY2013.pdf |
Filesize | 234,08 kB |
Version | o.170 |
Date added | Juni 6, 2020 |
Downloaded | 4 times |
Category | Original Work |
Tags | activity, angioedema, hereditary, urticaria, validation |
Authors | Weller, K., Groffik, A., Magerl, M., Tohme, N., Martus, P., Krause, K., Metz, M., Staubach, P., and Maurer, M. |
Citation | Weller, K., Groffik, A., Magerl, M., Tohme, N., Martus, P., Krause, K., Metz, M., Staubach, P., and Maurer, M.: Development, validation, and initial results of the angioedema activity score. Allergy 2013: 68; 1185-1192. |
Corresponding authors | Maurer, M. |
DocNum | O.170 |
DocType | |
Edition; Page | 68; 1185-1192 |
IF | 5.99 |
Publisher | Allergy |
ReleaseDate | 2013 |
Background: Recurrent angioedema (RecA) is a frequent clinical problem charac- terized by suddenly occurring cutaneous and/or mucosal swellings. Depending on their location, RecA may be painful, hindering, disfiguring, or even life-threaten- ing. The assessment of disease activity in affected patients is important to guide treatment decisions. Currently, however, there is no standardized and validated outcome measure available to do so.
Objective: To develop and validate the first specific patient-reported outcome instrument to assess disease activity in RecA patients, the Angioedema Activity Score (AAS).
Methods: After a set of potential AAS items was developed, item evaluation and reduction were performed by means of impact analysis, factor analysis, regression analysis, and by checking for face validity. In addition, the items of the final AAS questionnaire were tested for their validity and reliability during a 12-week validation study.
Results: In total, data from 110 and 80 RecA patients were used during the AAS item evaluation and validation phase, respectively. The resulting AAS consisted of five items and was found to have a one-dimensional structure and excellent internal consistency. It correlated well with other measures of disease activity and quality-of-life impairment, thus demonstrating its convergent validity. In addition, the known-groups validity and test–retest reliability of the AAS were found to be good.
Conclusions: The AAS is the first validated and reliable tool to determine disease activity in RecA patients, and it may serve as a valuable instrument in future clin- ical studies and routine patient care.
(Last update: 06.2024)
Number of original publications in peer-reviewed journals: | 612 |
Number of reviews in peer-reviewed journals: | 217 |
Number of publications (original work and reviews) in peer-reviewed journals: | 829 |
Cumulative IF for original publications in peer-reviewed journals: | 4364.99 |
Cumulative IF for reviews in peer-reviewed journals: | 1567.62 |
Cumulative IF of publications (original work & reviews) in peer-reviewed journals: | 5932.61 |
Total number of citations: 37,066, h-index: 98 (Web of Science Juni 2024) | 37066 |
Download-Information
Um die angebotenen Veröffentlichungen herunterladen zu können, müssen Sie sich einloggen. Wenn Sie das Login nicht kennen, schreiben Sie mir bitte Ihre Anfrage.