Veröffentlichungen
Originalarbeiten, Bücher, Buchkapitel und Übersichtsartikel von Prof. Marcus Maurer
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Effective control of recalcitrant pruritus by bevacizumab – a possible role for VEGF in chronic itch?
| Filename | 164. Krause et al, Eff.control of recalcitr. bevac. VEGF ActDerm2013.pdf |
| Filesize | 983,80 kB |
| Version | o.164 |
| Date added | Juni 5, 2020 |
| Downloaded | 0 times |
| Category | Original Work |
| Tags | itch, prurigo, Pruritus, VEGF |
| Authors | Krause, K., Krull, C., Keßler, B., Lange-Asschenfeldt, B., Maurer, M. and Metz, M. |
| Citation | Krause, K., Krull, C., Keßler, B., Lange-Asschenfeldt, B., Maurer, M. and Metz, M.: Effective control of recalcitrant pruritus by bevacizumab – a possible role for VEGF in chronic itch? Acta Derm. Venereol. 2013: 2; 175-179. |
| Corresponding authors | Metz, M. |
| DocNum | O.164 |
| DocType | |
| Edition; Page | 2; 175-179 |
| IF | 4.24 |
| Publisher | Acta Derm. Venereol. |
| ReleaseDate | 2013 |
Prurigo is a dif cult to treat condition characterized by severe pruritus presenting with chronic secondary scratch lesions. We report here a dramatic improvement in pruritus in a patient with prurigo simplex who was being treated with bevacizumab, a monoclonal vascular endothelial growth factor (VEGF) antibody. On the basis of the increased VEGF expression measured in the skin of this patient, serum levels of VEGF were subsequently analysed in 27 consecutive patients with prurigo and 19 healthy controls. VEGF levels were signi cantly in- creased in the serum of patients with prurigo. Moreover, VEGF concentrations correlated with physician-assessed disease activity. Based on these observations, we specula- te that VEGF is involved in the pathophysiology of pru- rigo.
(Last update: 12.2023)
| Number of original publications in peer-reviewed journals: | 580 |
| Number of reviews in peer-reviewed journals: | 210 |
| Number of publications (original work and reviews) in peer-reviewed journals: | 790 |
| Cumulative IF for original publications in peer-reviewed journals: | 4196.39 |
| Cumulative IF for reviews in peer-reviewed journals: | 1409.32 |
| Cumulative IF of publications (original work & reviews) in peer-reviewed journals: | 5605.71 |
| Total number of citations: 36,836, h-index: 99 (Web of Science December 2023) | 36836 |
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