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Originalarbeiten, Bücher, Buchkapitel und Übersichtsartikel von Prof. Marcus Maurer
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Effects of topical treatment with the raft modulator miltefosine and clobetasol in cutaneous mastocytosis: a randomized, double-blind, placebo-controlled trial
Filename | 95. Hartmann et al. Effects of topical treatm. miltefosine clobetasol,BJD 2010.pdf |
Filesize | 426,18 kB |
Version | o.095 |
Date added | Mai 27, 2020 |
Downloaded | 0 times |
Category | Original Work |
Authors | Hartmann, K., Siebenhaar, F., Belloni, B., Brockow, K., Eben, R., Hartmann, B., Ruëff, F., Schoepke, N., Staubach, P., Weber, A., and Maurer, M. |
Citation | Hartmann, K., Siebenhaar, F., Belloni, B., Brockow, K., Eben, R., Hartmann, B., Ruëff, F., Schoepke, N., Staubach, P., Weber, A., and Maurer, M.: Effects of topical treatment with the raft modulator miltefosine and clobetasol in cutaneous mastocytosis: a randomized double-blind, placebo-controlled trial. Brit. J. Dermatol. 2010: 162; 185-190. |
Corresponding authors | Hartmann, K. |
DocNum | O.95 |
DocType | |
Edition; Page | 162; 185-190 |
IF | 4.35 |
Publisher | Brit. J. Dermatol. |
ReleaseDate | 2010 |
Background: Mastocytosis is characterized by the accumulation and activation of mast cells in different organs, most commonly the skin. Miltefosine, a raft modulator, has recently been shown to inhibit the activation of mast cells and to reduce mast cell-driven skin inflammatory responses.
Objectives: To study the safety and efficacy of topical miltefosine treatment of skin lesions in patients with mastocytosis.
Methods: Thirty-nine adult patients with mastocytosis with skin involvement were treated in a double-blind, placebo-controlled, parallel trial with topical miltefosine and clobetasol for 2 weeks. Treatment areas were analysed for changes in skin lesions and symptoms following mechanical irritation using novel volumetric imaging techniques and quantitative histomorphometry.
Results: Miltefosine and clobetasol failed to reduce significantly weals and flare-type skin responses following mechanical provocation. Miltefosine showed a trend towards reducing the volume of weals. Clobetasol significantly decreased the volume of weals and the number of mast cells in the upper dermis. Treatment with miltefosine, but not with clobetasol, was often associated with eczematous skin irritation, which may, at least in part, be related to the formulation of miltefosine containing the potentially irritating alkanol propanediol as the vehicle.
Conclusions: Raft modulators such as miltefosine are promising candidates for novel therapeutic strategies in patients with cutaneous mastocytosis. Future studies should be performed with improved formulations using nonirritant vehicles.
(Last update: 12.2023)
Number of original publications in peer-reviewed journals: | 580 |
Number of reviews in peer-reviewed journals: | 210 |
Number of publications (original work and reviews) in peer-reviewed journals: | 790 |
Cumulative IF for original publications in peer-reviewed journals: | 4196.39 |
Cumulative IF for reviews in peer-reviewed journals: | 1409.32 |
Cumulative IF of publications (original work & reviews) in peer-reviewed journals: | 5605.71 |
Total number of citations: 36,836, h-index: 99 (Web of Science December 2023) | 36836 |
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