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How to assess disease activity in patients with chronic urticaria
Filename | 60. Mlynek et al,disease activity CU,Allergy 2008.pdf |
Filesize | 168,15 kB |
Version | o.060 |
Date added | Mai 26, 2020 |
Downloaded | 2 times |
Category | Original Work |
Authors | Młynek, A., Zalewska-Janowska, A., Martus, P., Staubach, P., Zuberbier, T., and Maurer, M. |
Citation | Młynek, A., Zalewska-Janowska, A., Martus, P., Staubach, P., Zuberbier, T., and Maurer, M.: How to assess disease activity in patients with chronic urticaria? Allergy 2008: 63; 777-780. IF: 6.20 |
Corresponding authors | Maurer, M. |
DocNum | O.60 |
DocType | |
Edition; Page | 63; 777-780 |
IF | 6.20 |
Publisher | Allergy |
ReleaseDate | 2008 |
Background: The current EAACI/GA2 LEN/EDF guidelines recommend assessing disease activity in chronic urticaria (CU) by using an established and well-defined symptom score, i.e. the urticaria activity score (UAS), which combines daily wheal numbers and pruritus intensity. However, this UAS has never been formally tested for its suitability in assessing CU activity.
Aim: To determine the UAS correlation with quality of life (QoL) in CU patients and to compare the UAS to other symptom scores.
Methods: Chronic urticaria symptoms (wheals, erythema, angioedema, pruritus)were assessed on seven consecutive days in 111 CU patients for their numbers, duration, size, and/or intensity. Quality of life was assessed by using the Dermatology Life Quality Index. Both, urticaria activity and QoL were determined before and after a 3-week period, in which the patients followed a pseudoallergen-low diet.
Results: Urticaria activity score values correlated positively, albeit weakly, with QoL impairment in CU patients (r 2 = 0.31, P < 0.05). Also, changes in QoL following a pseudoallergen-low diet were reflected by the changes observed in the UAS (r 2 = 0.30, P < 0.05). No significant differences were found comparing the QoL correlation of the UAS and other symptom scores combining up to four CU symptom qualities. Quality of life correlation with UAS values increased with the number of days the UAS was assessed and plateaued starting from the fourth consecutive day.
Conclusions: Our findings back the current guideline recommendations to use the UAS for monitoring disease activity in CU patients. Urticaria activity score mean values of at least four consecutive days should be used.
(Last update: 12.2023)
Number of original publications in peer-reviewed journals: | 580 |
Number of reviews in peer-reviewed journals: | 210 |
Number of publications (original work and reviews) in peer-reviewed journals: | 790 |
Cumulative IF for original publications in peer-reviewed journals: | 4196.39 |
Cumulative IF for reviews in peer-reviewed journals: | 1409.32 |
Cumulative IF of publications (original work & reviews) in peer-reviewed journals: | 5605.71 |
Total number of citations: 36,836, h-index: 99 (Web of Science December 2023) | 36836 |
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