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Originalarbeiten, Bücher, Buchkapitel und Übersichtsartikel von Prof. Marcus Maurer
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IL-9 production by regulatory T cells recruits mast cells that are essential for regulatory T cell-induced immune-suppression
Filename | 109. Eller et al,Il-9 prod. by reg. T cells, 2011 J Immunol.pdf |
Filesize | 1,05 MB |
Version | o.109 |
Date added | Mai 30, 2020 |
Downloaded | 0 times |
Category | Original Work |
Authors | Eller, K., Wolf, D., Huber, J. M., Metz, M., Mayer, G., McKenzie A. N. J., Maurer, M. Rosenkranz, A. R., and Wolf, A. M. |
Citation | Eller, K., Wolf, D., Huber, J. M., Metz, M., Mayer, G., McKenzie A. N. J., Maurer, M. Rosenkranz, A. R., and Wolf, A. M.: IL-9 production by regulatory T cells recruits mast cells that are essential for regulatory T cell-induced immune-suppression. J. Immunol. 2011: 186; 83-91. IF: 5.78 |
Corresponding authors | Rosenkranz, A. R. |
DocNum | O.109 |
DocType | |
Edition; Page | 186; 83-91 |
IF | 5.78 |
Publisher | J. Immunol. |
Both mast cells (MCs) and regulatory T cells (Tregs) have gained attention as immunosuppressive cell populations. To investigate a possible interaction, we used the Th1- and Th17-dependent model of nephrotoxic serum nephritis (NTS), in which both MCs and Tregs have been shown to play a protective role. Transfer of wild-type (wt) Tregs into wt recipients almost completely prevents development of NTS and leads to a profound increase of MCs in the renal draining lymph nodes (LNs). By contrast, transfer of wt Tregs into animals deficient in MCs, which are characterized by an exaggerated susceptibility to NTS, no longer exhibited protective effects. Blocking the pleiotropic cytokine IL-9, known to be involved in MC recruitment and proliferation, by means of a mAb in mice receiving Tregs abrogated protection from NTS. Moreover, transfer of IL-9–deficient Tregs also failed to protect from NTS. In the absence of Treg-derived IL-9, MCs fail to accumulate in the LNs, despite the fact that IL-9 deficiency does not alter the general suppressive activity of Tregs. In summary, to our knowledge, we provide the first direct in vivo evidence that the nephroprotective, anti-inflammatory effects of Tregs critically depend on IL-9–mediated attraction of MCs into kidney-draining LNs.
(Last update: 12.2023)
Number of original publications in peer-reviewed journals: | 580 |
Number of reviews in peer-reviewed journals: | 210 |
Number of publications (original work and reviews) in peer-reviewed journals: | 790 |
Cumulative IF for original publications in peer-reviewed journals: | 4196.39 |
Cumulative IF for reviews in peer-reviewed journals: | 1409.32 |
Cumulative IF of publications (original work & reviews) in peer-reviewed journals: | 5605.71 |
Total number of citations: 36,836, h-index: 99 (Web of Science December 2023) | 36836 |
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