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Originalarbeiten, Bücher, Buchkapitel und Übersichtsartikel von Prof. Marcus Maurer
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Immunoregulation in cutaneous allergy - prevention and control
Filename | 66. Zielinski et al., Immunoreg. cut. allergy,COACI 2012.pdf |
Filesize | 215,71 kB |
Version | r.066 |
Date added | Juni 26, 2020 |
Downloaded | 0 times |
Category | Reviews |
Tags | immunoregulation, skin, T regulatory cells |
Authors | Zielinski, C., Zuberbier, T., and Maurer, M. |
Citation | Zielinski, C., Zuberbier, T., and Maurer, M.: Immunoregulation in cutaneous allergy - prevention and control. Curr. Opin. Allergy Clin. Immunol. 2012: 12; 498-503. |
Corresponding authors | Zielinski, C. |
DocNum | r.66 |
DocType | |
Edition; Page | 12; 498-503 |
IF | 3.39 |
Publisher | Curr. Opin. Allergy Clin. Immunol. |
ReleaseDate | 2012 |
Purpose of review: The cutaneous surface is exposed to a myriad of encounters with chemicals, allergens and microbes. Nevertheless, it withstands these environmental assaults without overt inflammation. We will discuss the role of T regulatory cells in a situation where this tissue homeostasis fails – cutaneous allergy, in particular contact hypersensitivity.
Recent findings: Immune regulation is a complex process that is mediated by many cellular players. T regulatory cells have risen to particular prominence as potent immunosuppressors because their absence results in inflammation including skin allergy. Recent findings revealed that T regulatory cells comprise a heterogeneous group of subpopulations with specialized homing capabilities and suppressor functions. The stability of the
T regulatory cell subset in proinflammatory microenvironments is controversially discussed. In addition, it has recently been shown that mechanisms by which T regulatory cells exert their immunosuppressive functions can be adopted by pathogenic effector T cells in certain situations.
Summary:In cutaneous allergy, immunoregulatory mechanisms are dysfunctional. The cellular players comprise classical T regulatory cells as well as effector T cells with regulatory activities. Understanding their role in skin homeostasis and the mechanisms by which their regulatory functions are abrogated will yield novel therapeutic targets for the treatment of cutaneous allergies.
(Last update: 12.2023)
Number of original publications in peer-reviewed journals: | 580 |
Number of reviews in peer-reviewed journals: | 210 |
Number of publications (original work and reviews) in peer-reviewed journals: | 790 |
Cumulative IF for original publications in peer-reviewed journals: | 4196.39 |
Cumulative IF for reviews in peer-reviewed journals: | 1409.32 |
Cumulative IF of publications (original work & reviews) in peer-reviewed journals: | 5605.71 |
Total number of citations: 36,836, h-index: 99 (Web of Science December 2023) | 36836 |
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