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Mast cell biology and its role in the immediate skin contact reactions

Filename 30. Maurer et al. in Maibach, 4. MC Biology in immediate skin contact reactions, 2014.pdf
Filesize 2 MB
Version bc.30
Date added August 2, 2020
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Category Book Chapters
Authors Maurer, M., Siebenhaar, F., Schmetzer, O., and Metz, M.
Citation Maurer, M., Siebenhaar, F., Schmetzer, O., and Metz, M.: Mast cell biology and its role in the immediate skin contact reactions. In: Maibach, H. I. and Gimenez-Arnau, A., editors: Contact urticaria syndrome. 2nd ed., CRC Press, 2014
DocNum BC.30
DocType PDF
Edition; Page 2nd ed.
Editors Maibach, H. I. and Gimenez-Arnau, A.
Name of Book Contact urticaria syndrome
Publisher CRC Press
ReleaseDate 2014

The mechanisms underlying immediate contact skin reactions are only partially understood, especially regarding nonimmunologic contact urticaria (CoU) and protein contact dermatitis (PCD). Each trigger substance has its own mechanism or mechanisms of action. Nonimmunologic CoU is due to vasogenic mediators without the involvement of immunological processes. The pathogenesis of immunological CoU reflects a type I hypersensitivity reaction, mediated by allergen- specific immunoglobin E (IgE) in a previously sensitized individual. Skin challenge involves allergen penetration through the epidermis, IgE binding on mast cells (MCs), their degranulation, and subsequent release of histamine and other vasoactive substances such as prostaglandins, leukotrienes, and kinins (Figure 4.1).A combination of type I and type IV allergic skin reactions, the latter supported by positive delayed patch tests, has been suggested as PCD pathogenesis. It has been speculated that PCD is an eczematous IgE-mediated reaction through proteins. PCD shows a similar reaction pattern to aeroallergen-induced atopic eczema or dermatitis.In this chapter, we will focus on the characteristics involved in immunological immediate skin reactions, especially in CoU. The mast cell’s role is thoroughly discussed.

(Last update: 05.2021)

Number of publications (original work and reviews) in peer-reviewed journals: 624
Number of original publications in peer-reviewed journals: 450
Number of reviews in peer-reviewed journals: 174
Cumulative IF of publications (original work & reviews) in peer-reviewed journals: 3429,68
Cumulative IF for original publications in peer-reviewed journals: 2735,29
Cumulative IF for reviews in peer-reviewed journals: 694,39
Citations, Hirsch index: (view on Web of Science) 25219