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Mast cells and basophils are important members of the immune sys‐tem. Both of these cell types are implicated in allergic responses, being strongly responsive to activation/degranulation through aller‐gen‐induced crosslinking of IgE molecules bound to their high‐affin‐ity cell surface receptors (FcεRI). However, there have been intense research efforts during the past decades where the roles of mast cells and basophils in many contexts beyond allergy have been ex‐plored. These efforts have formed the basis for a much more com‐plex view of the biology of these cell types.1 For example, mast cells and basophils are strongly implicated in pruritus, cancer, various autoimmune disorders, chronic inflammation, urticaria, transplanta‐tion, wound healing, obesity, infertility and fibrosis.2‐7 In all of these conditions, mast cells and basophils have predominantly detrimental functions, but they are also known to have beneficial functions, most notably in the host protection against bacterial, fungal and parasitic insults, and against envenomation.