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Originalarbeiten, Bücher, Buchkapitel und Übersichtsartikel von Prof. Marcus Maurer
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p53 Is Essential for Chemotherapy-induced Hair Loss
Filename | 27. Original Botchkarev et al. P53 Chemotherypy Cancer Res 2000.pdf |
Filesize | 1,59 MB |
Version | o.027 |
Date added | Mai 20, 2020 |
Downloaded | 0 times |
Category | Original Work |
Authors | Botchkarev, V. A., Komarova, E. A., Siebenhaar, F., Botchkareva, N. V., Komarov, P. G., Maurer, M. Gilchrest, B. A., and Gudkov, A. V. |
Citation | Botchkarev, V. A., Komarova, E. A., Siebenhaar, F., Botchkareva, N. V., Komarov, P. G., Maurer, M. Gilchrest, B. A., and Gudkov, A. V.: p53 is essential for chemotherapy-induced hair loss. Cancer Res. 2000: 60; 5002-5006. |
Corresponding authors | Gudkov, A. V. |
DocNum | o.027 |
DocType | |
Edition; Page | 60; 5002-5006 |
IF | 8.46 |
Publisher | Cancer Res. |
ReleaseDate | 2000 |
Anticancer drugs stimulate apoptosis in the hair follicles (HF) and cause hair loss, the most common side effect of chemotherapy. In a mouse model for chemotherapy-induced hair loss, we demonstrate that p53 is essential for this process: in contrast to wild-type mice, p53-deficient mice show neither hair loss nor apoptosis in the HF keratinocytes that maintained active proliferation after cyclophosphamide treatment. HF in p53 mutants are characterized by down-regulation of Fas and insulin-like growth factor-binding protein 3 and by increased expression of Bcl-2. These observations indicate that local pharmacological inhibition of p53 may be useful to prevent chemotherapy-associated hair loss.
(Last update: 12.2023)
Number of original publications in peer-reviewed journals: | 580 |
Number of reviews in peer-reviewed journals: | 210 |
Number of publications (original work and reviews) in peer-reviewed journals: | 790 |
Cumulative IF for original publications in peer-reviewed journals: | 4196.39 |
Cumulative IF for reviews in peer-reviewed journals: | 1409.32 |
Cumulative IF of publications (original work & reviews) in peer-reviewed journals: | 5605.71 |
Total number of citations: 36,836, h-index: 99 (Web of Science December 2023) | 36836 |
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