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Prevalence and clinical characteristics of chronic spontaneous urticaria in pediatric patients
Filename | 324. Balp et al., Prev. clin. char. CSU pediatr., PEDAllImm2018.pdf |
Filesize | 557,85 kB |
Version | o.324 |
Date added | Juni 13, 2020 |
Downloaded | 0 times |
Category | Original Work |
Tags | angioedema, chronic spontaneous urticaria, Chronic Urticaria, Europe, pediatric, prevalence, treatment patterns |
Authors | Balp, M. M., Weller, K., Carboni, V., Chirilov, A., Papavassilis, C., Severin, T., Tian, H., Zuberbier, T., and Maurer, M. |
Citation | Balp, M. M., Weller, K., Carboni, V., Chirilov, A., Papavassilis, C., Severin, T., Tian, H., Zuberbier, T., and Maurer, M.: Prevalence and clinical characteristics of chronic spontaneous urticaria in pediatric patients. Pediatr. Allergy Immunol. 2018: 29; 630-636. |
Corresponding authors | Balp, M. M. |
DocNum | O.324 |
DocType | |
Edition; Page | 29; 630-636 |
IF | 2.42 |
Publisher | Pediatr. Allergy Immunol. |
ReleaseDate | 2018 |
Background: Data on the prevalence and disease management of chronic urticaria (CU) and chronic spontaneous urticaria (CSU) in the pediatric population are scarce. This study assessed the prevalence of CU and CSU, and disease management among pediatric patients (0-17 years).
Methods: A physician-based online survey was conducted in 5 European countries (United Kingdom, Germany, Italy, France, and Spain) assessing the annual diagnosed prevalence, disease characteristics, and treatment patterns in the target population. Results are based on physician responses and analyzed using descriptive statistics. Prevalence estimates were calculated based on the number of CU/CSU pediatric pa- tients diagnosed, seen, and treated by the respondents and extrapolated to the total pediatric population from each country.
Results: Across 5 European countries, the one-year diagnosed prevalence of CU and CSU in pediatric patients was 1.38% (95% CI, 0.94-1.86) and 0.75% (95% CI, 0.44- 1.08), respectively. Angioedema was reported in 6%-14% of patients. A large propor- tion of CSU pediatric patients (40%-60%) were treated with H1-antihistamines at approved dose and 16%-51% received H1-antihistamines at higher doses. Approximately 1/3 of pediatric CSU patients remained uncontrolled with H1- antihistamines at approved/higher doses. Other prescribed treatments were oral corticosteroids (10%-28%) and topical creams (15%-26%).
Conclusions: This study revealed a prevalence of CSU among pediatric population comparable to adults and also suggested an unmet need for approved treatments for inadequately controlled pediatric CSU patients. It is truly of concern that harmful (oral steroids) or insufficient (topical creams) treatments were frequently used de- spite better and guideline-recommended alternatives.
(Last update: 12.2023)
Number of original publications in peer-reviewed journals: | 580 |
Number of reviews in peer-reviewed journals: | 210 |
Number of publications (original work and reviews) in peer-reviewed journals: | 790 |
Cumulative IF for original publications in peer-reviewed journals: | 4196.39 |
Cumulative IF for reviews in peer-reviewed journals: | 1409.32 |
Cumulative IF of publications (original work & reviews) in peer-reviewed journals: | 5605.71 |
Total number of citations: 36,836, h-index: 99 (Web of Science December 2023) | 36836 |
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