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Originalarbeiten, Bücher, Buchkapitel und Übersichtsartikel von Prof. Marcus Maurer
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Rupatadine 20 mg and 40 mg are effective in reducing the symptoms of chronic cold urticaria
Filename | 232. Abajian et al.,Rupatadine 20-40 mg cold urt.,ActDermV2016.pdf |
Filesize | 1,38 MB |
Version | o.232 |
Date added | Juli 30, 2020 |
Downloaded | 4 times |
Category | Original Work |
Tags | chronic cold urticarial, H1-antihistamine, rupatadine, up-dosing |
Authors | Abajian, M., Curto-Barredo, L., Krause, K., Santamaria, E., Izquierdo, I., Church, M. K., Maurer, M. and Giménez-Arnau, A. |
Citation | Abajian, M., Curto-Barredo, L., Krause, K., Santamaria, E., Izquierdo, I., Church, M. K., Maurer, M. and Giménez-Arnau, A.: Rupatadine 20 mg and 40 mg are effective in reducing the symptoms of chronic cold urticaria. Acta Derm. Venereol. 2016: 96; 56-59. |
Corresponding authors | Giménez-Arnau, A |
DocNum | O.232 |
DocType | |
Edition; Page | 96; 56-59 |
IF | 3.65 |
Publisher | Acta Derm. Venereol. |
ReleaseDate | 2016 |
Chronic cold urticaria (ColdU) is a rare disease charac-terized by mast cell-mediated wheals and angioedema following cold exposure. Second-generation H1-anti-histamines, such as rupatadine, are the recommended first-line therapy. As of yet, the effects of rupatadine up-dosing on development of ColdU symptom have only been partially characterized. Two-centre, randomized, double-blind, 3-way crossover, placebo-controlled study in patients with a confirmed ColdU was designed to assess the effects of up-dosing of rupatadine. A total of 23 patients were randomized to receive placebo, rupatadine 20 mg/day, and rupatadine 40 mg/day for 1 week. The primary outcome was change in critical temperature thresholds and critical stimulation time thresholds af-ter treatment. Secondary endpoints included assessment of safety and tolerability of rupatadine. Both 20 and 40 mg rupatadine were highly effective in reducing critical temperature thresholds (p < 0.001) and critical stimula-tion time thresholds (p < 0.001). In conclusion, rupata-dine 20 and 40 mg significantly reduced the development of chronic cold urticaria symptom without an increase in adverse effects.
(Last update: 12.2023)
Number of original publications in peer-reviewed journals: | 580 |
Number of reviews in peer-reviewed journals: | 210 |
Number of publications (original work and reviews) in peer-reviewed journals: | 790 |
Cumulative IF for original publications in peer-reviewed journals: | 4196.39 |
Cumulative IF for reviews in peer-reviewed journals: | 1409.32 |
Cumulative IF of publications (original work & reviews) in peer-reviewed journals: | 5605.71 |
Total number of citations: 36,836, h-index: 99 (Web of Science December 2023) | 36836 |
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