Veröffentlichungen
Originalarbeiten, Bücher, Buchkapitel und Übersichtsartikel von Prof. Marcus Maurer
Verwendung: Beginnen Sie mit einer Übersicht über alle Publikationen. Verwenden Sie Tag-Links, um markierte Dokumente aufzulisten oder eine ganze Kategorie aufzulisten, z.B. Original Work (Originalarbeiten), Books (Bücher), Book Chapters (Buchkapitel), Reviews (Übersichtsartikel). Wenn Sie wissen, was Sie suchen, dann geben Sie diesen Begriff in das Suchfeld ein.
Safeguarding of fetal growth by mast cells and natural killer cells: deficiency of one is counterbalanced by the other
Filename | 275. Meyer et al., Safeguard. fetal growth MC, Frontiers Immun.2017 .pdf |
Filesize | 1,27 MB |
Version | o.275 |
Date added | Juli 29, 2020 |
Downloaded | 0 times |
Category | Original Work |
Tags | counter-regulation, mast cell-specific proteases, mast cells, natural killer cells, spiral arteries |
Authors | Meyer, N., Woidacki, K., Maurer, M. and Zenclussen, A. C. |
Citation | Meyer, N., Woidacki, K., Maurer, M. and Zenclussen, A. C.: Safeguarding of fetal growth by mast cells and natural killer cells: deficiency of one is counterbalanced by the other. Front. Immunol. 2017: 8; 711. |
Corresponding authors | Zenclussen, A. C. |
DocNum | O.275 |
DocType | |
Edition; Page | 8; 711 |
IF | 5.51 |
Publisher | Front. Immunol. |
ReleaseDate | 2017 |
Uterine natural killer cells (uNKs) and mast cells (uMCs) are of crucial importance for spiral artery (SA) remodeling and placentation. Mice deficient for both NKs and MCs including uNKs and uMCs show markedly impaired SA remodeling and their fetuses are growth-retarded. In contrast, the absence of either NKs or MCs results in only minor impairment. This suggests that uNKs can compensate for the effects of uMCs on SA remodeling and vice versa. To test this hypothesis, we assessed uNK numbers in uMC-deficient mice as well as uMC numbers in uNK-depleted mice. Notably, uMC- deficient C57BL/6J-KitW-sh/W-sh (W-sh) mice showed markedly increased numbers of uNKs in contrast to wild type, and the transfer of bone marrow-derived MCs reverted this phenotype. Vice versa, uNK-deficient C57BL/6NTac-IL15tm1ImxN5 (IL-15−/−) mice had significantly increased numbers of uMCs and MC-specific proteases. Our results suggest that uNKs and uMCs can counterbalance their effects at the feto–maternal interface and jointly promote SA remodeling and placentation.
(Last update: 12.2023)
Number of original publications in peer-reviewed journals: | 580 |
Number of reviews in peer-reviewed journals: | 210 |
Number of publications (original work and reviews) in peer-reviewed journals: | 790 |
Cumulative IF for original publications in peer-reviewed journals: | 4196.39 |
Cumulative IF for reviews in peer-reviewed journals: | 1409.32 |
Cumulative IF of publications (original work & reviews) in peer-reviewed journals: | 5605.71 |
Total number of citations: 36,836, h-index: 99 (Web of Science December 2023) | 36836 |
Download-Information
Um die angebotenen Veröffentlichungen herunterladen zu können, müssen Sie sich einloggen. Wenn Sie das Login nicht kennen, schreiben Sie mir bitte Ihre Anfrage.