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SARS-CoV-2 in severe COVID-19 induces a TGF-β-dominated chronic immune response that does not target itself

Filename 429. Ferreira-Gomes et al., TGF-beta, Nat Comm 2021.pdf
Filesize 6,44 MB
Version o.429
Date added Juni 1, 2021
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Category Original Work
Tags chronic immune response, Covid-19, SARS-­CoV-­2
Authors Ferreira-Gomes, M., Kruglov, A., Durek, P., Heinrich, F., Tizian, C., Heinz, G. A., Pascual-Reguant, A., Du, W., Mothes, R., Fan, C., Frischbutter, S., Habenicht, K., Budzinski, L., Ninnemann, J., Jani, P. K., Guerra, G., Lehmann, K., Matz, M., Ostendorf, L., Heiberger, L., Chang, H.-D., Bauherr, S., Maurer, M., Schönrich, G., Raftery, M., Kallinich, T., Mall, M. A., Angermair, S., Treskatsch, S., Dörner, T., Corman, V. M., Diefenbach, A., Volk, H.-D., Elezkurtaj, S., Winkler, T. H., Dong, J., Hauser, A. E., Radbruch, H., Witkowski, M., Melchers, F., Radbruch, A., and Mashreghi, M.-F.
Citation Ferreira-Gomes, M., Kruglov, A., Durek, P., Heinrich, F., Tizian, C., Heinz, G. A., Pascual-Reguant, A., Du, W., Mothes, R., Fan, C., Frischbutter, S., Habenicht, K., Budzinski, L., Ninnemann, J., Jani, P. K., Guerra, G., Lehmann, K., Matz, M., Ostendorf, L., Heiberger, L., Chang, H.-D., Bauherr, S., Maurer, M., Schönrich, G., Raftery, M., Kallinich, T., Mall, M. A., Angermair, S., Treskatsch, S., Dörner, T., Corman, V. M., Diefenbach, A., Volk, H.-D., Elezkurtaj, S., Winkler, T. H., Dong, J., Hauser, A. E., Radbruch, H., Witkowski, M., Melchers, F., Radbruch, A., and Mashreghi, M.-F.: SARS-CoV-2 in severe COVID-19 induces a TGF-β-dominated chronic immune response that does not target itself. Nat. Commun. 2021: 12; 1961.
Corresponding authors Mashreghi, M.-F.
DocNum o.429
DocType PDF
Equivalent authors Ferreira-Gomes, M., Kruglov, A., Durek, P., Heinrich, F., Tizian, C., Heinz, G. A., Radbruch, H., Witkowski, M., Melchers, F., Radbruch, A., and Mashreghi, M.-F.
IF 17.69
Publisher Nat. Commun.
ReleaseDate 2021

The pathogenesis of severe COVID-19 reflects an inefficient immune reaction to SARS-CoV-2. Here we analyze, at the single cell level, plasmablasts egressed into the blood to study thedynamics of adaptive immune response in COVID-19 patients requiring intensive care. Beforeseroconversion in response to SARS-CoV-2 spike protein, peripheral plasmablasts display atype 1 interferon-induced gene expression signature; however, following seroconversion,plasmablasts lose this signature, express instead gene signatures induced by IL-21 and TGF-β,and produce mostly IgG1 and IgA1. In the sustained immune reaction from COVID-19patients, plasmablasts shift to the expression of IgA2, thereby reflecting an instruction byTGF-β. Despite their continued presence in the blood, plasmablasts are not found in the lungsof deceased COVID-19 patients, nor does patient IgA2 binds to the dominant antigens ofSARS-CoV-2. Our results thus suggest that, in severe COVID-19, SARS-CoV-2 triggers achronic immune reaction that is instructed by TGF-β, and is distracted from itself.

 

(Last update: 12.2023)

Number of original publications in peer-reviewed journals:580
Number of reviews in peer-reviewed journals:210
Number of publications (original work and reviews) in peer-reviewed journals:790
Cumulative IF for original publications in peer-reviewed journals:4196.39
Cumulative IF for reviews in peer-reviewed journals:1409.32
Cumulative IF of publications (original work & reviews) in peer-reviewed journals:5605.71
Total number of citations: 36,836, h-index: 99 (Web of Science December 2023)36836

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