Veröffentlichungen
Originalarbeiten, Bücher, Buchkapitel und Übersichtsartikel von Prof. Marcus Maurer
Verwendung: Beginnen Sie mit einer Übersicht über alle Publikationen. Verwenden Sie Tag-Links, um markierte Dokumente aufzulisten oder eine ganze Kategorie aufzulisten, z.B. Original Work (Originalarbeiten), Books (Bücher), Book Chapters (Buchkapitel), Reviews (Übersichtsartikel). Wenn Sie wissen, was Sie suchen, dann geben Sie diesen Begriff in das Suchfeld ein.
Serum neuron specific enolase – a novel indicator for neuropsychiatric systemic lupus erythematosus?
Filename | 227. Hawro et al., Lupus eryth.,LUPUS 2015.pdf |
Filesize | 157,38 kB |
Version | o.227 |
Date added | Juli 30, 2020 |
Downloaded | 0 times |
Category | Original Work |
Tags | Biomarker, central nervous system diseases, chronic brain damage, neuron specific enolase, Phosphopyruvate hydratase, systemic lupus erythematosus |
Authors | Hawro, T., Bogucki, A., Krupińska-Kun, M., Maurer, M., and Woźniacka, A. |
Citation | Hawro, T., Bogucki, A., Krupińska-Kun, M., Maurer, M., and Woźniacka, A.: Serum neuron specific enolase – a novel indicator for neuropsychiatric systemic lupus erythematosus? Lupus 2015: 24; 1492-1497. |
Corresponding authors | Maurer, M. |
DocNum | o.227 |
DocType | |
Edition; Page | 24; 1492-1497 |
IF | 2.11 |
Publisher | Lupus |
ReleaseDate | 2015 |
Objective: Neuropsychiatric (NP) lupus, a common manifestation of systemic lupus erythematosus (SLE), is still insufficiently understood, in part, because of the lack of specific bio-markers. Neuron specific enolase (NSE), an important neuronal glycolytic enzyme, showsincreased serum levels following acute brain injury, and decreased serum levels in severalchronic disorders of the nervous system, including multi infarct dementia, multiple sclerosisand depression. The aim of the study was to evaluate serum NSE levels in SLE patients withand without nervous system involvement, and in healthy controls, and to assess the correlationof NSE serum levels of patients with neuropsychiatric systemic lupus erythematosus (NPSLE)with clinical parameters.
Methods: The study comprised 47 SLE patients and 28 controls. SLEactivity was assessed using the Systemic Lupus Activity Measure (SLAM). A neurologist and apsychiatrist examined all patients. NP involvement was diagnosed according to strict NPSLEcriteria proposed by Ainiala and coworkers, as modification to American College ofRheumatology (ACR) nomenclature and case definitions. NSE serum levels were determinedby use of an immunoassay.
Results: Mean NSE serum concentrations in patients with NPSLEwere significantly lower than in non-NPSLE patients (6.32.6mg/L vs. 9.73.3mg/L,p<0.01) and in controls (8.83.3mg/L,p<0.05). There were significant negative correlationsbetween NSE serum levels and SLE activity (r¼0.42,p<0.05) and the number of NPSLEmanifestations diagnosed (0.37;p¼0.001).
Conclusion: Decreased serum concentrations ofNSE may reflect chronic neuronal damage with declined metabolism of the nervous tissue inpatients with NPSLE.Lupus(2015)24,1492–1497.
(Last update: 12.2023)
Number of original publications in peer-reviewed journals: | 580 |
Number of reviews in peer-reviewed journals: | 210 |
Number of publications (original work and reviews) in peer-reviewed journals: | 790 |
Cumulative IF for original publications in peer-reviewed journals: | 4196.39 |
Cumulative IF for reviews in peer-reviewed journals: | 1409.32 |
Cumulative IF of publications (original work & reviews) in peer-reviewed journals: | 5605.71 |
Total number of citations: 36,836, h-index: 99 (Web of Science December 2023) | 36836 |
Download-Information
Um die angebotenen Veröffentlichungen herunterladen zu können, müssen Sie sich einloggen. Wenn Sie das Login nicht kennen, schreiben Sie mir bitte Ihre Anfrage.