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Originalarbeiten, Bücher, Buchkapitel und Übersichtsartikel von Prof. Marcus Maurer
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Similar Efficacy with Omalizumab in Chronic Idiopathic/Spontaneous Urticaria Despite Different Background Therapy
Filename | 211. Casale et al., Similar eff. omalizumab ciu csu, JACI Pract. 2015.pdf |
Filesize | 550,92 kB |
Version | o.211 |
Date added | Juli 29, 2020 |
Downloaded | 0 times |
Category | Original Work |
Tags | Antihistamine, Chronic idiopathic, Chronic spontaneous, hive, itch, omalizumab, Pruritus, urticaria, wheal |
Authors | Casale, T. B., Bernstein, J. A., Maurer, M. Saini, S. S., Trzaskoma, B., Chen, H., Grattan, C., Gimenèz-Arnau, A., Kaplan, A. P., and Rosén, K. |
Citation | Casale, T. B., Bernstein, J. A., Maurer, M. Saini, S. S., Trzaskoma, B., Chen, H., Grattan, C., Gimenèz-Arnau, A., Kaplan, A. P., and Rosén, K.: Similar efficacy with Omalizumab in chronic idiopathic/spontaneous urticaria despite different background therapy. J. Allergy Clin. Immunol. Pract. 2015: 3; 743-750. |
Corresponding authors | Rosén, K. |
DocNum | O.211 |
DocType | |
Edition; Page | 3; 743-750 |
IF | 5.42 |
Publisher | J. Allergy Clin. Immunol. Pract. |
ReleaseDate | 2015 |
Background: Data from the 3 omalizumab pivotal trials inpatients with chronic idiopathic urticaria/chronic spontaneous urticaria (CIU/CSU) represent the largest database of patients reported to date with refractory disease (omalizumab, n[733;placebo, n[242).
Objective: The objective of this study was to compare results from ASTERIA I and II, which included only approved doses ofH1-antihistamine as background therapy based on regulatory authority requirements, to those from GLACIAL, which permitted higher doses of H1-antihistamines as well as other types of background therapy, in aposthocanalysis.
Methods: Efficacy data from the placebo, omalizumab 150-mg, and omalizumab 300-mg treatment arms of ASTERIA I andII were pooled and analyzed (n[162 and n[160, respectively). The 300-mg treatment arm analyses were compared with the analysis of data from GLACIAL (n[252) using analysis of covariance models. The key efficacy endpoint was change from baseline to week 12 in mean weekly itch severity score (ISS);
(Last update: 12.2023)
Number of original publications in peer-reviewed journals: | 580 |
Number of reviews in peer-reviewed journals: | 210 |
Number of publications (original work and reviews) in peer-reviewed journals: | 790 |
Cumulative IF for original publications in peer-reviewed journals: | 4196.39 |
Cumulative IF for reviews in peer-reviewed journals: | 1409.32 |
Cumulative IF of publications (original work & reviews) in peer-reviewed journals: | 5605.71 |
Total number of citations: 36,836, h-index: 99 (Web of Science December 2023) | 36836 |
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