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Originalarbeiten, Bücher, Buchkapitel und Übersichtsartikel von Prof. Marcus Maurer
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Skin mast cells contribute to Sporothrix schenkii infection
| Filename | 375. Jiao et al., Sporothrix, FrontImmunol 2020.pdf |
| Filesize | 1,38 MB |
| Version | o.375 |
| Date added | Juni 5, 2020 |
| Downloaded | 2 times |
| Category | Original Work |
| Authors | Jiao, Q., Luo, Y., Scheffel, J., Geng, P., Wang, Y., Frischbutter, S., Li, R., Maurer, M., and Zhao, Z. |
| Citation | Jiao, Q., Luo, Y., Scheffel, J., Geng, P., Wang, Y., Frischbutter, S., Li, R., Maurer, M., and Zhao, Z.: Skin mast cells contribute to Sporothrix schenkii infection. Front. Immunol. 2020: 11; 469 |
| Corresponding authors | Maurer, M., and Zhao, Z. |
| DocNum | o.375 |
| DocType | |
| Edition; Page | 11; 469 |
| IF | 7.56 |
| Publisher | Front. Immunol. |
| ReleaseDate | 2020 |
Background: Sporothrix schenckii (S. schenckii), a dimorphic fungus, causes sporotrichosis. Mast cells (MCs) have been described to be involved in skin fungal infections. The role of MCs in cutaneous sporotrichosis remains largely unknown.
Objectives: To characterize the role and relevance of MCs in cutaneous sporotrichosis.
Methods: We analyzed cutaneous sporotrichosis in wild-type (WT) mice and two different MC-deficient strains. In vitro, MCs were assessed for S. schenckii-induced cytokine production and degranulation after incubation with S. schenckii. We also explored the role of MCs in human cutaneous sporotrichosis.
Results: WT mice developed markedly larger skin lesions than MC-deficient mice (> 1.5 fold) after infection with S. schenckii, with significantly increased fungal burden. S. schenckii induced the release of tumor necrosis factor alpha (TNF), interleukin (IL)-6, IL10, and IL-1β by MCs, but not degranulation. S. schenckii induced larger skin lesions and higher release of IL-6 and TNF by MCs as compared to the less virulent S. albicans. Inpatients with sporotrichosis, TNF and IL-6 were increased in skin lesions, and markedly elevated levels in the serum were linked to disease activity.
Conclusions: These findings suggest that cutaneous MCs contribute to skin sporotrichosis by releasing cytokines such as TNF and IL-6.
(Last update: 12.2023)
| Number of original publications in peer-reviewed journals: | 580 |
| Number of reviews in peer-reviewed journals: | 210 |
| Number of publications (original work and reviews) in peer-reviewed journals: | 790 |
| Cumulative IF for original publications in peer-reviewed journals: | 4196.39 |
| Cumulative IF for reviews in peer-reviewed journals: | 1409.32 |
| Cumulative IF of publications (original work & reviews) in peer-reviewed journals: | 5605.71 |
| Total number of citations: 36,836, h-index: 99 (Web of Science December 2023) | 36836 |
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