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The icatibant outcome survey: treatment of laryngeal angioedema attacks
| Filename | 234. Longhurst et al., Icatibant Outcome S.,EJEM 2016.pdf |
| Filesize | 80,25 kB |
| Version | o.234 |
| Date added | Juli 30, 2020 |
| Downloaded | 0 times |
| Category | Original Work |
| Tags | acquired angioedema, C1 inhibitor deficiency, Hereditary Angioedema, Icatibant, laryngeal edema, observational study, therapy |
| Authors | Longhurst, H. J., Aberer, W., Bouillet, L., Caballero, T., Maurer, M. Fabien, V., Zanichelli, A. |
| Citation | Longhurst, H. J., Aberer, W., Bouillet, L., Caballero, T., Maurer, M. Fabien, V., Zanichelli, A.: The icatibant outcome survey: treatment of laryngeal angioedema attacks. Eur. J. Emerg. Med. 2016: 23; 224-227. |
| Corresponding authors | Longhurst, H. J. |
| DocNum | O.234 |
| DocType | |
| Edition; Page | 23; 224-227 |
| IF | 2.02 |
| Publisher | Eur. J. Emerg. Med. |
| ReleaseDate | 2016 |
Objective: To characterize the management and outcomes of life-threatening laryngeal attacks of hereditary angioedema (HAE) treated with icatibant in the observational Icatibant Outcome Survey (NCT01034969) registry.
Methods: This retrospective analysis was based on data from patients with HAE type I/II who received health care professional-administered or self-administered icatibant to treat laryngeal attacks between September 2008 and May2013.
Results: Twenty centers in seven countries contributed data. Overall, 42 patients with HAE experienced 67icatibant-treated laryngeal attacks. Icatibant was self-administered for 62.3% of attacks (healthcare professional-administered, 37.7%). One icatibant injection was used for87.9% of attacks, with rescue or concomitant medicationused for 9.0%. The median time to treatment was 2.0 h(n=31 attacks) and the median time to resolution was 6.0 h(n=35 attacks).
Conclusions: This analysis describes successful use of icatibant for the treatment of laryngeal HAE attacks in a real-world setting.European Journal of Emergency Medicine00:000–000 Copyright © 2015 Wolters Kluwer Health, Inc.All rights reserved.
(Last update: 12.2023)
| Number of original publications in peer-reviewed journals: | 580 |
| Number of reviews in peer-reviewed journals: | 210 |
| Number of publications (original work and reviews) in peer-reviewed journals: | 790 |
| Cumulative IF for original publications in peer-reviewed journals: | 4196.39 |
| Cumulative IF for reviews in peer-reviewed journals: | 1409.32 |
| Cumulative IF of publications (original work & reviews) in peer-reviewed journals: | 5605.71 |
| Total number of citations: 36,836, h-index: 99 (Web of Science December 2023) | 36836 |
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