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Originalarbeiten, Bücher, Buchkapitel und Übersichtsartikel von Prof. Marcus Maurer
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The role of innate immunity in asthma: leads and lessons from mouse models
Filename | 20. Schröder & Maurer,Role of inn. imm. asthma.Allergy 2007.pdf |
Filesize | 776,45 kB |
Version | r.020 |
Date added | Juni 21, 2020 |
Downloaded | 0 times |
Category | Reviews |
Tags | asthma, dendritic cells, mast cells, mouse models, Toll-like receptors |
Authors | Schröder, N. W. J. and Maurer, M. |
Citation | Schröder, N. W. J. and Maurer, M.: The role of innate immunity in asthma: leads and lessons from mouse models. Allergy 2007: 62; 579-590. |
Corresponding authors | Maurer, M. |
DocNum | R.20 |
DocType | |
Edition; Page | 62; 579-590 |
IF | 5.01 |
Publisher | Allergy |
ReleaseDate | 2007 |
According to the Hygiene Hypothesis, respiratory infections should protect individuals from allergic diseases including asthma, but epidemiologic data on the role of infections or exposure to microbial compounds in asthma are contradictory. Meanwhile, a number of murine models of airway sensitization are available facilitating the elucidation of pathways involved in asthma pathogenesis. Such studies have linked antigen presentation by activated pulmonary dendritic cells (DCs) with airway sensitization. Toll-like receptors (TLRs), which play a major role in innate immunity by sensing various microbial compounds, are expressed on
DCs, as well as on mast cells (MCs). Activation of TLRs by administration of specific bacterial ligands, in particular lipopolysaccharide, can augment airway sensitization in mice, and there is evidence that this process involves TLRdependent activation of DCs. Intriguingly, viral infection has been shown to increase airway inflammation in a murine asthma model via activation of DCs as well. TLR-4-dependent stimulation of MCs may also play a role in allergic sensitization in mice, and in vitro studies in murine cells show that ligation of TLRs expressed on MCs enhances degranulation. Therefore, evidence obtained from studies on mice indicates that innate immune responses may promote, rather than protect from, the development as well as the exacerbation of asthma.
(Last update: 12.2023)
Number of original publications in peer-reviewed journals: | 580 |
Number of reviews in peer-reviewed journals: | 210 |
Number of publications (original work and reviews) in peer-reviewed journals: | 790 |
Cumulative IF for original publications in peer-reviewed journals: | 4196.39 |
Cumulative IF for reviews in peer-reviewed journals: | 1409.32 |
Cumulative IF of publications (original work & reviews) in peer-reviewed journals: | 5605.71 |
Total number of citations: 36,836, h-index: 99 (Web of Science December 2023) | 36836 |
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