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Originalarbeiten, Bücher, Buchkapitel und Übersichtsartikel von Prof. Marcus Maurer
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The role of Interleukin-1 in allergy-related disorders
| Filename | 64. Krause et al Role of IL1 COACI 2012.pdf |
| Filesize | 324,39 kB |
| Version | r.064 |
| Date added | Juni 26, 2020 |
| Downloaded | 0 times |
| Category | Reviews |
| Tags | Allergy, inflammasome, interleukin-1, urticaria |
| Authors | Krause, K., Metz, M., Makris, M., Zuberbier, T., and Maurer, M. |
| Citation | Krause, K., Metz, M., Makris, M., Zuberbier, T., and Maurer, M.: The role of Interleukin-1 in allergy-related disorders. Curr. Opin. Allergy Clin. Immunol. 2012: 12; 477-484. |
| Corresponding authors | Krause, K. |
| DocNum | R.64 |
| DocType | |
| Edition; Page | 12; 477-484 |
| IF | 3.39 |
| Publisher | Curr. Opin. Allergy Clin. Immunol. |
| ReleaseDate | 2012 |
Purpose of review: Interleukin-1b (IL-1b) is a potent proinflammatory cytokine, which is involved in many inflammatory conditions including autoinflammatory and allergic disorders. This review provides insights into recent advances of our understanding of the pathogenesis of IL-1b-associated allergy-related disorders.
Recent findings: In autoinflammatory as well as allergic diseases such as contact hypersensitivity, atopic dermatitis and bronchial asthma, dysfunctional inflammasome processing has been demonstrated to account for IL-1b- induced inflammation. IL-1-neutralizing drugs have been shown to completely suppress or markedly reduce inflammatory responses in clinical studies and experimental models of urticarial autoinflammatory diseases as well as common allergic disorders.
Summary: The recent findings support a crucial role for IL-1b and inflammasome components in a variety of allergy- related disorders.
(Last update: 12.2023)
| Number of original publications in peer-reviewed journals: | 580 |
| Number of reviews in peer-reviewed journals: | 210 |
| Number of publications (original work and reviews) in peer-reviewed journals: | 790 |
| Cumulative IF for original publications in peer-reviewed journals: | 4196.39 |
| Cumulative IF for reviews in peer-reviewed journals: | 1409.32 |
| Cumulative IF of publications (original work & reviews) in peer-reviewed journals: | 5605.71 |
| Total number of citations: 36,836, h-index: 99 (Web of Science December 2023) | 36836 |
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