Publications, Books, Book Chapters and Reviews by Prof. Marcus Maurer, MD
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A simulated car-driving study on the effects of acute administration of levocetirizine, fexofenadine, and diphenhydramine in healthy Japanese volunteers
|Filename||235. Inami et al., Car-driving study, HumPsychClin2016.pdf|
|Date added||July 30, 2020|
|Tags||antihistamines, diphenhydramine, fexofenadine, levocetirizine, sedation, simulated car-driving|
|Authors||Inami, A., Matsuda, R., Grobosch, T., Komamura, H., Takeda, K., Yamada, Y., Miyake, M., Hiraoka, K., Maurer, M. Yanai, K., and Tashiro, M.|
|Citation||Inami, A., Matsuda, R., Grobosch, T., Komamura, H., Takeda, K., Yamada, Y., Miyake, M., Hiraoka, K., Maurer, M. Yanai, K., and Tashiro, M.: A simulated car-driving study on the effects of acute administration of levocetirizine, fexofenadine, and diphenhydramine in healthy Japanese volunteers. Hum. Psychopharmacol. Clin. Exp. 2016: 31; 167-177.|
|Corresponding authors||Tashiro, M.|
|Edition; Page||31; 167-177|
|Publisher||Hum. Psychopharmacol. Clin. Exp.|
Objective: Antihistamines are often used for treating allergic rhinitis. However, many older antihistamines cause sedative side effects. The sedative effects of antihistamines on car-driving have been investigated. This has not been investigated for levocetirizine, a new-generation antihistamine, in Asian populations, and so we evaluated its sedative effects in healthy Japanese subjects.
Methods: In this double-blind, placebo-controlled, four-way crossover study, healthy volunteers received single doses of levocetirizine 5 mg, fexofenadine 60 mg, diphenhydramine 50 mg, and placebo at intervals of at least 6 days. Simple brake reaction time and choice brake reaction time task (CBRT), a lateral tracking (LT) task, and a multiple task, a mixture of CBRT and LT task, were used to compare driving performance between the four drugs. Subjective sedation was also assessed.
Results: The simple brake reaction time and CBRT, and the CBRT component of the multiple task, did not show any significant differences between the drugs. In contrast, the LT, both as a single parameter and as a component of the multiple task, showed significant differences between diphenhydramine and the newer-generation antihistamines in a manner that corresponds with subjective sedation.
Conclusions: Levocetirizine and fexofenadine did not impair psychomotor performance in subjects performing simulated car-driving tasks, while diphenhydramine did impair psychomotor performance in the subjects. Copyright © 2016 John Wiley & Sons, Ltd.
(Last update: 08.2021)
|Number of publications (original work and reviews) in peer-reviewed journals:||636|
|Number of original publications in peer-reviewed journals:||462|
|Number of reviews in peer-reviewed journals:||174|
|Cumulative IF of publications (original work & reviews) in peer-reviewed journals:||3834,12|
|Cumulative IF for original publications in peer-reviewed journals:||3043,14|
|Cumulative IF for reviews in peer-reviewed journals:||790,98|
|Citations, Hirsch index: (view on Web of Science)||26429|