Publications, Books, Book Chapters and Reviews by Prof. Marcus Maurer, MD

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Angioedema quality of life questionnaire (AE-QoL) - interpretability and sensitivity to change

Filename 364. Kulthanan et al., Thai AE-QoL,HQLO 2019 Open Access.pdf
Filesize 473 KB
Version o.364
Date added June 8, 2019
Downloaded 3 times
Category Original Work
Tags angioedema, Clinimetric properties, Interpretability, Patient reported outcome, Quality of life, Questionnaire, Reliability, Validity
Authors Kulthanan, K., Chularojanamontri, L., Rujitharanawong, C., Weerasubpong, P., Maurer, M., and Weller, K.
Citation Kulthanan, K., Chularojanamontri, L., Rujitharanawong, C., Weerasubpong, P., Maurer, M., and Weller, K.: Angioedema quality of life questionnaire (AE-QoL) – interpretability and sensitivity to change. Health. Qual. Life Outcomes 2019: 17; 160. 
Corresponding authors Maurer, M.
DocNum o.364
DocType PDF
Edition; Page 17; 160
IF 2.34
Publisher Health. Qual. Life Outcomes
ReleaseDate 2019

Background: The Angioedema Quality of Life (AE-QoL) is the first patient reported outcome measure developed for the assessment of quality of life (QoL) impairment in patients with recurrent angioedema (RAE). This study aimed to evaluate the clinimetric properties of the AE-QoL in Thai patients and to establish categories of QoL impairment assessed by the AE-QoL.

Methods: The validated Thai version of the Dermatology Life Quality Index (DLQI) and Patient Global Assessment of Quality of Life (PGA-QoL) were used to comparatively evaluate the Thai version of AE-QoL. Spearman correlations between the Thai AE-QoL and two other standard measurements (DLQI and PGA-QoL) were investigated to determine convergent validity. The Thai DLQI and PGA-QoL were used to categorize patients according to their QoL. Knowngroup validity of the Thai AE-QoL was later analyzed. The reliability of the Thai AE-QoL was investigated using Cronbach’s alpha and intraclass correlation. Three different approaches including the distribution method, receiver operating characteristic curve analysis, and the anchor based-method were used for the interpretability.

Results: A total of 86 patients with RAE with a median age of 38.0 ± 15.1 years (range 18–76) were enrolled. Of those, 76 patients (88%) had RAE with concomitant wheals, and 10 patients (11.6%) had RAE only. The AE-QoL assessed RAE-mediated QoL impairment with high convergent validity and known-groups validity, high internal consistency and test-retest reliability, and good sensitivity to change. Although the AE-QoL did not differentiate between patients with moderate and large effect as measured by PGA-QoL or DLQI in this study, AE-QoL total values of 0–23, 24 to 38, and ≥ 39 could define patients with “no effect”, “small effect”, and “moderate to large effect” of RAE on their QoL, respectively.

Conclusions: This study supports the validity and reliability of the Thai version of the AE-QoL, which is a very different language from the original version. Categories allow to classify the effect of RAE on patients’ QoL as “none”, “small”, and “moderate to large”. Further studies are needed to confirm the applicability of AE-QoL in other Asian populations”.

(Last update: 08.2021)

Number of publications (original work and reviews) in peer-reviewed journals: 636
Number of original publications in peer-reviewed journals: 462
Number of reviews in peer-reviewed journals: 174
Cumulative IF of publications (original work & reviews) in peer-reviewed journals: 3834,12
Cumulative IF for original publications in peer-reviewed journals: 3043,14
Cumulative IF for reviews in peer-reviewed journals: 790,98
Citations, Hirsch index: (view on Web of Science) 26429