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Publications, Books, Book Chapters and Reviews by Prof. Marcus Maurer, MD

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ASSURE-CSU: a real-world study of burden of disease in patients with symptomatic chronic spontaneous urticaria

Filename 219. Weller et al.,ASSURE-CSU, CTA 2015.pdf
Filesize 798.54 KB
Version o.219
Date added July 30, 2020
Downloaded 0 times
Category Original Work
Tags Absenteeism, angioedema, Chronic idiopathic urticaria, chronic spontaneous urticaria, Disease burden, Economic cost, Humanisticburden, Observational, Presenteeism
Authors Weller, K., Maurer, M. Grattan, C., Nakonechna, A., Abuzakouk, M., Bérard, F., Sussman, G., Giménez-Arnau, A. M., Ortiz de Frutos, J., Knulst, A., Canonica, G. W., Hollis, K., McBride, D., and Balp, M. M.
Citation Weller, K., Maurer, M. Grattan, C., Nakonechna, A., Abuzakouk, M., Bérard, F., Sussman, G., Giménez-Arnau, A. M., Ortiz de Frutos, J., Knulst, A., Canonica, G. W., Hollis, K., McBride, D., and Balp, M. M.: ASSURE-CSU: a real-world study of burden of disease in patients with symptomatic chronic spontaneous urticaria. Clin. Transl. Allergy 2015: 5; 29.
Corresponding authors Weller, K.
DocNum O.219
DocType PDF
Edition; Page 5; 29
IF N/A
Publisher Clin. Transl. Allergy
ReleaseDate 2015

Background: Chronic spontaneous urticaria (CSU) formerly known as chronic idiopathic urticaria (CIU) is a severe and distressing skin condition that remains uncontrolled in approximately one half of patients, despite the use of licensed, recommended doses of modern, second-generation H1-antihistamines. So far, the humanistic, societal and economic burden of CSU/CIU has not been well quantified. Therefore it is important to broaden our understanding of how CSU/CIU impacts patients, society, and healthcare systems, by determining the disease burden of CSU/CIU and the associated unmet need; as well as to further guide the use of new treatments in an efficient and cost-effective manner.

Methods: ASSURE-CSU is an observational, multi center study being conducted in the UK, Germany, Canada, France,Italy, Spain, and The Netherlands. The study comprises a retrospective medical chart review in conjunction with patient surveys (including validated tools for assessment of disease impact) and an 8-day patient diary. The primary objectives of the study are to describe patient demographics, medical history, treatments, and healthcare resource utilization based on medical-record data and to assess the impact of disease, healthcare resource utilization, work days missed,and productivity loss based on patient-reported data. Approximately 700 patients (aged≥18 years) will be enrolled who have CSU/CIU despite currently receiving treatment, and have had persistent symptoms for at least 12 months.Data will be collected retrospectively for the 12 months (±1 month) prior to enrollment wherever possible, and prospectively for the week following enrollment.

Discussion: ASSURE-CSU will be the first study to examine the economic and humanistic burden of disease in patients diagnosed with CSU/CIU who are symptomatic despite treatment. By combining retrospective evaluation of medical records with prospective patient surveys and 8-day diaries, across seven different countries, the ASSURE-CSU study will contribute to a better understanding and acknowledgement of the burden of disease in patients with symptomatic chronic spontaneous urticaria.

 

(Last update: 12.2023)

Number of original publications in peer-reviewed journals:580
Number of reviews in peer-reviewed journals:210
Number of publications (original work and reviews) in peer-reviewed journals:790
Cumulative IF for original publications in peer-reviewed journals:4196.39
Cumulative IF for reviews in peer-reviewed journals:1409.32
Cumulative IF of publications (original work & reviews) in peer-reviewed journals:5605.71
Total number of citations: 36,836, h-index: 99 (Web of Science December 2023)36836

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