Publications
Publications, Books, Book Chapters and Reviews by Prof. Marcus Maurer, MD
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Autologous Whole Blood Injections to Patients with Chronic Urticaria and a Positive Autologous Serum Skin Test: A Placebo-Controlled Trial
Filename | 44. Staubach, Aut.whole blood chr. urt, Dermat.2006.pdf |
Filesize | 233.23 KB |
Version | o.044 |
Date added | May 20, 2020 |
Downloaded | 0 times |
Category | Original Work |
Authors | Staubach, P., Onnen, K., Vonend, A., Metz, M., Siebenhaar, F., Tschentscher, I., Opper, B., Magerl, M., Lüdtke, R., Kromminga, A., and Maurer, M. |
Citation | Staubach, P., Onnen, K., Vonend, A., Metz, M., Siebenhaar, F., Tschentscher, I., Opper, B., Magerl, M., Lüdtke, R., Kromminga, A., and Maurer, M.: Autologous whole blood injections to patients with chronic urticaria and a positive autologous serum skin test: A placebo-controlled trial. Dermatology 2006: 212; 150-159. IF: 1.85 |
Corresponding authors | Maurer, M. |
DocNum | O.44 |
DocType | |
Edition; Page | 212; 150-159 |
IF | 1.85 |
Publisher | Dermatology |
ReleaseDate | 2006 |
Patients with chronic urticaria (CU) frequently exhibit positive skin test reactions to autologous serum (ASST). Therapies aimed at inducing tolerance to circulating histamine-releasing factors in ASST+ CU patients, e.g. by treatment with autologous whole blood (AWB), have not yet been tested. Objective: To test whether ASST+ CU patients can benefit from repeated low-dose intramuscular injections of AWB. Methods: We characterized CU severity and duration, anti-Fc3RI and anti-IgE expression, use of antihistamines, and quality of life in 56 CU patients (ASST+: 35, ASST–: 21) and assessed the therapeutic effects of 8 weekly AWB injections in a randomized, placebo-controlled, single-blind, parallel-group trial. Results: Numbers, size, intensity, and/or duration of CU symptoms, quality of life, as well as expression of anti-Fc3RI or anti-IgE were similar in ASST+ and ASST– CU patients. However, CU in ASST+ patients was of longer duration and required markedly more antihistaminic medication. Interestingly, ASST+ patients, but not ASST– patients, showed significantly (1) reduced CU activity, (2) decreased use of antihistamines, and (3) improved quality of life after AWB treatment. Placebo treatment was ineffective in both groups, but differences of AWB and placebo treatment responses did not achieve statistical signif cance in either group, most likely due to the limited number of patients treated. Conclusion: Our findings suggest that ASST+ CU is clinically different from other CU subforms and that ASST+ CU patients can benefit from AWB therapy.
(Last update: 12.2023)
Number of original publications in peer-reviewed journals: | 580 |
Number of reviews in peer-reviewed journals: | 210 |
Number of publications (original work and reviews) in peer-reviewed journals: | 790 |
Cumulative IF for original publications in peer-reviewed journals: | 4196.39 |
Cumulative IF for reviews in peer-reviewed journals: | 1409.32 |
Cumulative IF of publications (original work & reviews) in peer-reviewed journals: | 5605.71 |
Total number of citations: 36,836, h-index: 99 (Web of Science December 2023) | 36836 |
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