Publications
Publications, Books, Book Chapters and Reviews by Prof. Marcus Maurer, MD
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Calcitonin gene-related peptide and vascular endothelial growth factor are expressed in lesional but not uninvolved skin in chronic spontaneous urticaria
Filename | 188. Kay et al., Calcitronin gene-related,CEA2014.pdf |
Filesize | 591.22 KB |
Version | o.188 |
Date added | June 6, 2020 |
Downloaded | 0 times |
Category | Original Work |
Tags | CGRP, chronic spontaneous urticaria, VEGF |
Authors | Kay, A. B., Ying, S., Ardelean, E., Młynek, A., Kita, H., Clark, P., and Maurer, M. |
Citation | Kay, A. B., Ying, S., Ardelean, E., Młynek, A., Kita, H., Clark, P., and Maurer, M.: Calcitonin gene-related peptide and vascular endothelial growth factor are expressed in lesional but not uninvolved skin in chronic spontaneous urticaria. Clin. Exp. Allergy 2014: 44; 1053-1060. |
Corresponding authors | Kay, A. B. |
DocNum | O.188 |
DocType | |
Edition; Page | 44; 1053-1060 |
IF | 4.77 |
Publisher | Clin. Exp. Allergy |
ReleaseDate | 2014 |
Background: The mechanisms for producing weals in chronic spontaneous (idiopathic) urticaria (CSU) are incompletely understood. Leucocyte infiltration with vascular leakage and expression of the potent vasoactive agents’ calcitonin gene-related peptide (CGRP) and vascular endothelial growth factor (VEGF) are features of late-phase allergic skin reactions, previously proposed as a model of CSU.
Objective: To measure CGRP and VEGF expression in lesional and non-lesional skin from CSU patients and to compare results with a control group.
Methods: Eight paired biopsies (one from 4–8 h spontaneous weals and one from unin- volved skin) were taken from eight patients with CSU and nine control subjects and stud- ied by immunohistochemistry and confocal microscopy.
Results: Lesional skin in CSU contained significantly more CGRP+ and VEGF+ cells than non-lesional skin. No significant differences were observed in CGRP and VEGF expression between non-lesional skin and controls. In lesional skin, VEGF and CGRP co-localised to UEA-1+ blood vessels. CGRP was also expressed by neutrophils and eosinophils and to a lesser extent by CD90+ fibroblasts, mast cells, CD3+ and CD68+ cells. CGRP and VEGF expression was not related to the duration of disease.
Conclusion and Clinical Relevance: Increased expression of CGRP and VEGF in lesional, but not uninvolved, skin indicates that these potent vasoactive agents may play a role in wealing and tissue oedema in CSU so representing novel targets in therapy.
(Last update: 12.2023)
Number of original publications in peer-reviewed journals: | 580 |
Number of reviews in peer-reviewed journals: | 210 |
Number of publications (original work and reviews) in peer-reviewed journals: | 790 |
Cumulative IF for original publications in peer-reviewed journals: | 4196.39 |
Cumulative IF for reviews in peer-reviewed journals: | 1409.32 |
Cumulative IF of publications (original work & reviews) in peer-reviewed journals: | 5605.71 |
Total number of citations: 36,836, h-index: 99 (Web of Science December 2023) | 36836 |
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