Publications
Publications, Books, Book Chapters and Reviews by Prof. Marcus Maurer, MD
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Cardioprotective C-kit+ bone marrow cells attenuate apoptosis after acute myocardial infarction in mice – in vivo assessment with fluorescence molecular imaging
Filename | 177. Ale et al., Cardioprot. C-kit bone marrow.THERAN.2013.pdf |
Filesize | 1.66 MB |
Version | o.177 |
Date added | June 6, 2020 |
Downloaded | 0 times |
Category | Original Work |
Authors | Ale, A., Siebenhaar, F., Kosanke, K., Aichler, M., Radrich, K., Heydrich, S., Schiemann, M., Bielicki, I., Noel, P. B., Braren, R., Maurer, M. Walch, A. K., Rummeny, E. J., Nztiachristos, V., and Wildgruber, M. |
Citation | Ale, A., Siebenhaar, F., Kosanke, K., Aichler, M., Radrich, K., Heydrich, S., Schiemann, M., Bielicki, I., Noel, P. B., Braren, R., Maurer, M. Walch, A. K., Rummeny, E. J., Nztiachristos, V., and Wildgruber, M.: Cardioprotective C-kit+ bone marrow cells attenuate apoptosis after acute myocardial infarction in mice – in vivo assessment with fluorescence molecular imaging. Theranostics 2013: 3; 903-913. |
Corresponding authors | Wildgruber, M. |
DocNum | o.177 |
DocType | |
Edition; Page | 3; 903-913 |
IF | 7.83 |
Publisher | Theranostics |
ReleaseDate | 2013 |
Cardiomyocyte loss via apoptosis plays a crucial role in ventricular remodeling following myo- cardial infarction (MI). Cell-based therapy approaches using bone marrow derived c-kit+ plu- ripotent cells may attenuate apoptosis following ischemic injury. We therefore thought to examine the early course of apoptosis following myocardial infarction – in-vivo – and non-invasively deter- mine the effect of c-kit+ bone marrow cells on post-MI remodeling. We studied apoptosis in wild-type Kit+/+, c-kit mutant KitW/KitW-v and KitW/KitW-v mice after cell therapy with bone-marrow derived c-kit+ cells after ischemia-reperfusion injury. Mice were followed by hybrid Fluorescence Molecular Tomography/X-ray Computed Tomography (FMT-XCT) at 6h, 24h and 7 days after ischemia-reperfusion injury using an Annexin V-based fluorescent nanosensor targeting phospha- tidylserine. KitW/KitW-v mice showed increased and prolonged apoptosis compared to control Kit+/+ mice while c-kit cell therapy was able to attenuate the altered apoptosis rates. Increased apoptosis was accompanied by severe decline in heart function, determined by cardiac Magnetic Resonance Imaging, and cell therapy was able to rescue the animals from deleterious heart failure. Post-mortem cryoslicing and immunohistochemistry localized the fluorescence signal of the An- nexin V sensor within the infarcted myocardium. Flow cytometry of digested infarct specimens identified apoptotic cardiomyocytes as the major source for the in-vivo Annexin V signal.
In-vivo molecular imaging using hybrid FMT-XCT reveals increased cardiomyocyte apoptosis in KitW/KitW-v mice and shows that c-kit+ cardioprotective cells are able to attenuate post-MI apoptosis and rescue mice from progressive heart failure.
(Last update: 12.2023)
Number of original publications in peer-reviewed journals: | 580 |
Number of reviews in peer-reviewed journals: | 210 |
Number of publications (original work and reviews) in peer-reviewed journals: | 790 |
Cumulative IF for original publications in peer-reviewed journals: | 4196.39 |
Cumulative IF for reviews in peer-reviewed journals: | 1409.32 |
Cumulative IF of publications (original work & reviews) in peer-reviewed journals: | 5605.71 |
Total number of citations: 36,836, h-index: 99 (Web of Science December 2023) | 36836 |
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