Publications, Books, Book Chapters and Reviews by Prof. Marcus Maurer, MD

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Chronic inducible urticaria: a systematic review of treatment options

Filename 135. Dressler et al., CIU syst. review, JACI 2018.pdf
Filesize 1 MB
Version r.135
Date added June 17, 2020
Downloaded 3 times
Category Reviews
Tags angioedema, antihistamines, inducible urticaria, omalizu- mab, review, urticaria
Authors Dressler, C., Werner, R. N., Eisert, L., Zuberbier, T., Nast, A., and Maurer, M.
Citation Dressler, C., Werner, R. N., Eisert, L., Zuberbier, T., Nast, A., and Maurer, M.: Chronic inducible urticaria: a systematic review of treatment options. J. Allergy Clin. Immunol. 2018: 141; 1726-1734.
Corresponding authors Maurer, M.
DocNum r.135
DocType PDF
Edition; Page 141; 1726-1734
IF 14.11
Publisher J. Allergy Clin. Immunol.
ReleaseDate 2018

Background: Chronic inducible urticaria (CindU) is a condition characterized by the appearance of recurrent wheals, angioedema, or both as a response to specific and reproducible triggers.

Objective: We sought to systematically assess evidence on the efficacy and safety of treatment options for CindU. Results were used to inform the 2017 update of “The EAACI/GA2LEN/EDF/ WAO guideline for the definition, classification, diagnosis and management of urticaria.’’

Methods: Randomized controlled trials and controlled intervention studies were searched systematically in various databases. Included studies were evaluated with the Cochrane Risk of Bias tool. Where possible, results from single studies were meta-analyzed, applying the Mantel-Haenszel approach by using a random-effects model (Der Simonian–Laird).

Results: We identified 30 studies that included patients with cold urticaria, symptomatic dermographism, delayed-pressure urticaria, or cholinergic urticaria. No studies on other forms of CindU were eligible. Risk of bias was often rated as unclear or high. Overall, second-generation antihistamines were more effective than placebo, and available data indicate that updosing might be effective. Omalizumab proved effective in patients with symptomatic dermographism, who did not respond to antihistamines. Detailed results are given for each type of CindU.

Conclusions: The available evidence is limited by small samples, heterogeneous efficacy outcomes, and poor reporting quality in many of the included studies. The findings are congruent with the suggested stepwise approach to treating CindUs. However, the data do not allow for drawing specific conclusions for specific subtypes of CindU. (J Allergy Clin Immunol 2018;141:1726-34.)

(Last update: 08.2021)

Number of publications (original work and reviews) in peer-reviewed journals: 636
Number of original publications in peer-reviewed journals: 462
Number of reviews in peer-reviewed journals: 174
Cumulative IF of publications (original work & reviews) in peer-reviewed journals: 3834,12
Cumulative IF for original publications in peer-reviewed journals: 3043,14
Cumulative IF for reviews in peer-reviewed journals: 790,98
Citations, Hirsch index: (view on Web of Science) 26429