Publications, Books, Book Chapters and Reviews by Prof. Marcus Maurer, MD

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Chronic spontaneous urticaria and internal parasites – a systematic review

Filename 103. Kolkhir et al., CSU and internal parasites, ALLERGY2016.pdf
Filesize 420 KB
Version r.103
Date added June 23, 2020
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Category Reviews
Tags chronic spontaneous urticaria, parasites, pathogenesis, prevalence
Authors Kolkhir, P., Balakirski, G., Merk, H. F., Olisova, O., and Maurer, M.
Citation Kolkhir, P., Balakirski, G., Merk, H. F., Olisova, O., and Maurer, M.: Chronic spontaneous urticaria and internal parasites – a systematic review. Allergy 2016: 71; 308-322.
Corresponding authors Maurer, M.
DocNum r.103
DocType PDF
Edition; Page 71; 308-322.
IF 7.36
Publisher Allergy
ReleaseDate 2016

Chronic spontaneous urticaria (CSU) is defined as persistent wheals, angioedema, or both lasting for >6 weeks due to known or unknown causes. Some epidemio- logical studies and case reports suggest that internal parasite infections (PI) can cause CSU. Here, we provide a systematic overview of published findings on the prevalence and relevance of PI in CSU and we discuss possible pathomechanisms. The prevalence of PI in CSU was investigated by 39 independent studies and comorbidity reportedly ranged from 0 to 75.4% (two-thirds of these studies reported infection rates of 10% or less). The prevalence of PI in adult and pedi- atric CSU patients ranged from 0% to 75.4% and from 0% to 37.8%, respec- tively. CSU patients were more often diagnosed with protozoa and had a significantly higher risk of toxocariasis seropositivity and Anisakis simplex sensiti- zation when compared to healthy controls. Patients with chronic urticaria more frequently had seropositivity of fasciolosis, Anisakis simplex sensitization, and the presence of Blastocystis hominis allele 34 (ST3) as compared with control subjects. In 21 studies, efficacy of treatment with antiparasitic drugs ranged from 0 to 100% (35.7% of 269 CSU patients benefitted). In 9 (42.8%) of 21 studies, more than 50% of efficacy was observed. The reported rate of urticaria comorbidity in PI patients in 18 independent studies is 1–66.7%. Urticaria including CSU might be a quite common symptom of strongyloidiasis and blastocystosis. Pathogenic mechanisms in CSU due to PI may include specific IgE, Th2 cytokine skewing, eosinophils, activation of the complement, and the coagulation systems.

(Last update: 08.2021)

Number of publications (original work and reviews) in peer-reviewed journals: 636
Number of original publications in peer-reviewed journals: 462
Number of reviews in peer-reviewed journals: 174
Cumulative IF of publications (original work & reviews) in peer-reviewed journals: 3834,12
Cumulative IF for original publications in peer-reviewed journals: 3043,14
Cumulative IF for reviews in peer-reviewed journals: 790,98
Citations, Hirsch index: (view on Web of Science) 26429