Publications

Publications, Books, Book Chapters and Reviews by Prof. Marcus Maurer, MD

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Comorbidity of chronic spontaneous urticaria and autoimmune thyroid diseases: a systematic review

Filename 126. Kolkhir et al., Comorbidity CSU, Allergy2017.pdf
Filesize 779.44 KB
Version r.126
Date added June 21, 2020
Downloaded 4 times
Category Reviews
Tags autoimmune thyroid disease, chronic spontaneous urticaria, Graves’ disease, Hashimoto’s thyroiditis, prevalence
Authors Kolkhir, P., Metz, M., Altrichter, S., and Maurer, M.
Citation Kolkhir, P., Metz, M., Altrichter, S., and Maurer, M.: Comorbidity of chronic spontaneous urticaria and autoimmune thyroid diseases: a systematic review. Allergy 2017: 72; 1440-1460.
Corresponding authors Maurer, M.
DocNum r.126
DocType PDF
Edition; Page 72; 1440-1460
IF 6.05
Publisher Allergy
ReleaseDate 2017

Patients with chronic spontaneous urticaria (CSU) are widely held to often have other autoimmune disorders, including autoimmune thyroid disease. Here, we sys- tematically evaluated the literature on the prevalence of thyroid autoimmunity in CSU and vice versa. There is a strong link between CSU and elevated levels of IgG antithyroid autoantibodies (AAbs), with most of a large number of studies reporting rates of ≥10%. Levels of IgG against thyroid peroxidase (TPO) are more often ele- vated in CSU than those of other IgG antithyroid AAbs (strong evidence). Levels of IgG antithyroid AAbs are more often elevated in adult patients with CSU than in children (strong evidence). Patients with CSU exhibit significantly higher levels of IgG antithyroid AAbs (strong evidence) and IgE-anti-TPO (weak evidence) than con- trols. Elevated IgG antithyroid AAbs in CSU are linked to the use of glucocorticoids (weak evidence) but not to disease duration or severity/activity, gender, age, or ASST response (inconsistent evidence). Thyroid dysfunction rates are increased in patients with CSU (strong evidence). Hypothyroidism and Hashimoto’s thyroiditis are more common than hyperthyroidism and Graves’ disease (strong evidence). Thy- roid dysfunction is more common in adult patients with CSU than in children (strong evidence) and in female than in male patients with CSU (weak evidence). Urticaria including CSU is more prevalent in patients with thyroid autoimmunity than in con- trols (weak evidence). CSU can improve in response to treatment with levothyroxine or other thyroid drugs (strong evidence). Pathogenic mechanisms in CSU patients with thyroid autoimmunity may include IgE against autoantigens, immune com- plexes, and complement.

 

(Last update: 12.2023)

Number of original publications in peer-reviewed journals:580
Number of reviews in peer-reviewed journals:210
Number of publications (original work and reviews) in peer-reviewed journals:790
Cumulative IF for original publications in peer-reviewed journals:4196.39
Cumulative IF for reviews in peer-reviewed journals:1409.32
Cumulative IF of publications (original work & reviews) in peer-reviewed journals:5605.71
Total number of citations: 36,836, h-index: 99 (Web of Science December 2023)36836

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