Publications, Books, Book Chapters and Reviews by Prof. Marcus Maurer, MD

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Current and future therapies for treating chronic spontaneous urticaria

Filename 105. Maurer et al., Current and future ther. CSU,ExpOpPharm2016.pdf
Filesize 1,013 KB
Version r.105
Date added June 23, 2020
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Category Reviews
Tags Alternative drugs, antihistamines, chronic spontaneous urticaria, ciclosporin, montelukast, omalizumab
Authors Maurer, M., Vena, G. A., Cassano, N., and Zuberbier, T.
Citation Maurer, M., Vena, G. A., Cassano, N., and Zuberbier, T.: Current and future therapies for treating chronic spontaneous urticaria. Expert Opin. Pharmacother. 2016: 17; 1131-1139.
Corresponding authors Vena, G. A.
DocNum r.105
DocType PDF
Edition; Page 17; 1131-1139.
IF 3.89
Publisher Expert Opin. Pharmacother.
ReleaseDate 2016

Introduction: Chronic spontaneous urticaria (CSU) is a disabling condition that causes deterioration of quality of life.

Areas covered: The international EAACI/GA2LEN/EDF/WAO guidelines have provided a stepwise treat- ment algorithm for CSU management. Second-generation H1-antihistamines are the first-line treatment, and the second step is the up-dosing of the same drugs. In refractory patients, the guidelines recommend the addition of omalizumab, ciclosporin A or montelukast. Systemic corticosteroids can be used as a short course during acute exacerbations. A plethora of alternative treatments has been evaluated, although the overall level of evidence for such treatments is low. Future treatment options may include inhibitors of skin mast cells and antagonists to mast cell-activating signals that are relevant for the induction of CSU signs and symptoms.

Expert opinion: The only licensed options included in the guidelines algorithm are standard-dosed second-generation H1-antihistamines and omalizumab. High-quality evidence has documented a rapid and strong symptomatic effect of omalizumab in CSU, although the optimal long-term regimens should be further investigated. The role of alternative drugs deserves additional studies. The potential of the existing treatments for inducing remission of CSU is unknown, and this is an important area of research, as is the evaluation of predictors of response, prognostic factors, and pathomechanisms.

(Last update: 08.2021)

Number of publications (original work and reviews) in peer-reviewed journals: 636
Number of original publications in peer-reviewed journals: 462
Number of reviews in peer-reviewed journals: 174
Cumulative IF of publications (original work & reviews) in peer-reviewed journals: 3834,12
Cumulative IF for original publications in peer-reviewed journals: 3043,14
Cumulative IF for reviews in peer-reviewed journals: 790,98
Citations, Hirsch index: (view on Web of Science) 26429