Publications, Books, Book Chapters and Reviews by Prof. Marcus Maurer, MD
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Development of a standardized pulse-controlled ergometry test for diagnosing and investigating cholinergic urticaria
|Filename||186. Altrichter et al., Devel. ergometry test cholU, DERM.SC.2014.pdf|
|Date added||June 6, 2020|
|Tags||cholinergic urticaria, diagnosis, Ergometry, Temperature|
|Authors||Altrichter, S., Salow, J., Ardelean, E., Church, M. K., Werner, A., and Maurer, M.|
|Citation||Altrichter, S., Salow, J., Ardelean, E., Church, M. K., Werner, A., and Maurer, M.: Development of a standardized pulse-controlled ergometry test for diagnosing and investigating cholinergic urticaria. J. Dermatol. Sci. 2014: 75; 88-93.|
|Corresponding authors||Church, M. K.|
|Edition; Page||75; 88-93|
|Publisher||J. Dermatol. Sci.|
Background: Cholinergic urticaria (CholU) is a common condition in which active or passive warming leads to development of pinpoint wheals, flares and itch.
Objective: To develop a standardized protocol for diagnosing CholU and measuring trigger thresholds, independent of patients’ fitness levels.
Method: Ten CholU patients and matched healthy controls underwent pulse-controlled incremental ergometry for 30 min (stationary bicycle) increasing their pulse rate by 15 beats every 5 min. Non- invasive, heat-flux double-sensor and conventional electronic thermometers measured core and skin surface temperatures from which mean body temperature (MBT) was calculated. The time of onset of sweating (starch-iodine test) and symptoms (whealing) were recorded.
Results: All individuals completed the ergometry protocol without difficulty. All CholU patients but no controls developed wheals. The time to whealing correlated inversely with disease severity. In four patients MBT increased <0.5 8C and in two whealing occurred at a temperature lower than at the start of exercise. Onset of symptoms correlated with the time of sweating.
Conclusion: Pulse-controlled ergometry is sensitive and specific for diagnosing CholU and investigating trigger thresholds and disease mechanisms. Our results refute the hypothesis that a rise in MBT is the critical trigger for CholU while sweating appears to have the central role.
(Last update: 12.2022)
|Number of original publications in peer-reviewed journals:||531|
|Number of reviews in peer-reviewed journals:||191|
|Number of publications (original work and reviews) in peer-reviewed journals:||722|
|Cumulative IF for original publications in peer-reviewed journals:||3784.58|
|Cumulative IF for reviews in peer-reviewed journals:||1064.33|
|Cumulative IF of publications (original work & reviews) in peer-reviewed journals:||4848.91|
|Total number of citations: 31,392, h-index: 90 (Web of Science December 2022)||31392|