Publications
Publications, Books, Book Chapters and Reviews by Prof. Marcus Maurer, MD
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Differences and similarities in the mechanisms and clinical expression of bradykinin-mediated vs. mast cell-mediated angioedema
Filename | 169. Maurer et al., Biologics for the use CSU,JACIinPract2021.pdf |
Filesize | 2.06 MB |
Version | r.169 |
Date added | March 15, 2021 |
Downloaded | 3 times |
Category | Reviews |
Tags | angioedema, Anti-IgE receptor, Antihistamine, basophils, chronic spontaneous urticaria, eosinophils, mast cells, Novel biologics, omalizumab |
Authors | Maurer, M., Khan, D. A., Komi, D. E. A., and Kaplan, A. P. |
Citation | Maurer, M., Khan, D. A., Komi, D. E. A., and Kaplan, A. P.: Biologics for the use in chronic spontaneous urticaria: when and which? J. Allergy Clin. Immunol. Pract. 2021: 9; 1067-1078. |
Corresponding authors | Maurer, M. |
DocNum | r.169 |
DocType | |
IF | 11.02 |
Publisher | Clin. Rev. Allerg. Immunol. |
ReleaseDate | 2021 |
Guidelines for the treatment of chronic spontaneous urticaria (CSU) recommend the use of the IgE-targeted biologic omalizumab in patients with antihistamine-refractory disease. The rationale for this is supported by the key role of IgE and its high-affinity receptor, FcεRI, in the degranulation of skin mast cells that drives the development of the signs and symptoms of CSU, itchy wheals, and angioedema. Here, we review the current understanding of the pathogenesis of CSU and its autoimmune endotypes. We describe the mechanisms of action of omalizumab, the only biologic currently approved for CSU, its efficacy and ways to improve it, biomarkers for treatment response, and strategies for its discontinuation. We provide information on the effects of the off-label use, in CSU, of biologics licensed for the treatment of other diseases, including dupilumab, benralizumab, mepolizumab, reslizumab, and secukinumab. Finally, we discuss targets for novel biologics and where we stand with their clinical development. These include IgE/ligelizumab, IgE/GI-310, thymic stromal lymphopoietin/tezepelumab, C5a receptor/avdoralimab, sialic acidebinding Ig-like lectin 8/lirentelimab, CD200R/LY3454738, and KIT/CDX-0159. Our aim is to provide updated information and guidance on the use of biologics in the treatment of patients with CSU, now and in the near future. 2020 American Academy of Allergy, Asthma & Immunology (J Allergy Clin Immunol Pract 2021;9:1067-78)
(Last update: 12.2023)
Number of original publications in peer-reviewed journals: | 580 |
Number of reviews in peer-reviewed journals: | 210 |
Number of publications (original work and reviews) in peer-reviewed journals: | 790 |
Cumulative IF for original publications in peer-reviewed journals: | 4196.39 |
Cumulative IF for reviews in peer-reviewed journals: | 1409.32 |
Cumulative IF of publications (original work & reviews) in peer-reviewed journals: | 5605.71 |
Total number of citations: 36,836, h-index: 99 (Web of Science December 2023) | 36836 |
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