Publications

Publications, Books, Book Chapters and Reviews by Prof. Marcus Maurer, MD

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Effects of levocetirizine and diphenhydramine on regional glucose metabolic changes and hemodynamic responses in the human prefrontal cortex during cognitive tasks

Filename 305. Kikuchi et al., Levocetirizine, HUP 2018.pdf
Filesize 2 MB
Version o.305
Date added June 9, 2020
Downloaded 1 time
Category Original Work
Tags antihistamines, diphenhydramine, FDG‐PET, levocetirizine, NIRS, sedation
Authors Kikuchi, A., Inami, A., Nasir, F. B. M., Mohsen, A., Watanuki, S., Miyake, M., Matsuda, R., Koike, D., Ito, T., Sasakawa, J., Takeda, K., Hiraoka, K., Maurer, M. Yanai, K., Watabe, H., and Tashiro, M.
Citation Kikuchi, A., Inami, A., Nasir, F. B. M., Mohsen, A., Watanuki, S., Miyake, M., Matsuda, R., Koike, D., Ito, T., Sasakawa, J., Takeda, K., Hiraoka, K., Maurer, M. Yanai, K., Watabe, H., and Tashiro, M.: Effects of levocetirizine and diphenhydramine on regional glucose metabolic changes and hemodynamic responses in the human prefrontal cortex during cognitive tasks. Hum. Psychopharmacol. Clin. Exp. 2018: 33; e2655.
Corresponding authors Tashiro, M.
DocNum O.305
DocType PDF
Edition; Page 33; e2655
IF 2.26
Publisher Hum. Psychopharmacol. Clin. Exp.
ReleaseDate 2018

Objective: Antihistamines often have sedative side effects. This was the first study to mea- sure regional cerebral glucose (energy) consumption and hemodynamic responses in young adults during cognitive tests after antihistamine administration.

Methods: In this double‐blind, placebo‐controlled, three‐way crossover study, 18 healthy young Japanese men received single doses of levocetirizine 5 mg and diphenhydramine 50 mg at intervals of at least six days. Subjective feeling, task performances, and brain activity were evaluated during three cognitive tests (word fluency, two‐back, and Stroop). Regional cerebral glucose consumption changes were measured using positron emission tomography with [18F]fluorodeoxyglucose. Regional hemodynamic responses were measured using near‐infrared spectroscopy.

Results: Energy consumption in prefrontal regions was significantly increased after antihista- mine administration, especially diphenhydramine, whereas prefrontal hemodynamic responses, evaluated with oxygenated hemoglobin levels, were significantly lower with diphenhydramine treatment. Stroop test accuracy was significantly impaired by diphenhydramine, but not by levocetirizine. There was no significant difference in subjective sleepiness.

Conclusions: Physiological “coupling” between metabolism and perfusion in the healthy human brain may not be maintained under pharmacological influence due to antihistamines. This uncoupling may be caused by a combination of increased energy demands in the prefrontal regions and suppression of vascular permeability in brain capillaries after antihistamine treatment. Further research is needed to validate this hypothesis.

(Last update: 08.2021)

Number of publications (original work and reviews) in peer-reviewed journals: 636
Number of original publications in peer-reviewed journals: 462
Number of reviews in peer-reviewed journals: 174
Cumulative IF of publications (original work & reviews) in peer-reviewed journals: 3834,12
Cumulative IF for original publications in peer-reviewed journals: 3043,14
Cumulative IF for reviews in peer-reviewed journals: 790,98
Citations, Hirsch index: (view on Web of Science) 26429