Publications
Publications, Books, Book Chapters and Reviews by Prof. Marcus Maurer, MD
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Efficacy and safety of treatment with omalizumab for chronic spontaneous urticaria – a systematic review for the EAACI biologicals guidelines
Filename | 412. Agache et al., Eff and saf. Oma EAACI biol, Allergy 2021.pdf |
Filesize | 697.43 KB |
Version | o.412 |
Date added | March 17, 2021 |
Downloaded | 1 time |
Category | Original Work |
Tags | Chronic idiopathic urticaria, chronic spontaneous urticaria, itch severity score, omalizumab, Urticaria Activity Score |
Authors | Agache, I., Rocha, C., Pereira, A., Song, Y., Alonso-Coello, P., Solà, I., Beltran, J., Posso, M., Akdis, C., Akdis, M., Brockow, K., Chivato, T., del Giacco, S., Eiwegger, T., Eyerich, K., Giménez-Arnau, A., Gutermuth, J., Guttman-Yassky, E., Maurer, M., Ogg, G., Ong, P., O’Mahony, L., Schwarze, J., Werfel, T., Canelo-Aybar, C., Palomares, O., and Jutel, M. |
Citation | Agache, I., Rocha, C., Pereira, A., Song, Y., Alonso-Coello, P., Solà, I., Beltran, J., Posso, M., Akdis, C., Akdis, M., Brockow, K., Chivato, T., del Giacco, S., Eiwegger, T., Eyerich, K., Giménez-Arnau, A., Gutermuth, J., Guttman-Yassky, E., Maurer, M., Ogg, G., Ong, P., O’Mahony, L., Schwarze, J., Werfel, T., Canelo-Aybar, C., Palomares, O., and Jutel, M.: Efficacy and safety of treatment with omalizumab for chronic spontaneous urticaria – a systematic review for the EAACI biologicals guidelines. Allergy 2021: 76; 59-70. |
Corresponding authors | Agache, I. |
DocNum | o.412 |
DocType | |
IF | 14.71 |
Publisher | Allergy |
ReleaseDate | 2021 |
This systematic review evaluates the efficacy and safety of omalizumab for chronic spontaneous urticaria (CSU). PubMed, Embase, and Cochrane Library were searched for RCTs. Critical and important CSU-related outcomes were considered. The risk of bias and the certainty of the evidence were assessed using GRADE. Ten RCTs includ- ing 1620 subjects aged 12 to 75 years old treated with omalizumab for 16 to 40 weeks were evaluated. Omalizumab 150 mg does not result in clinically meaningful improve- ment (high certainty) of the urticaria activity score (UAS)7 (mean difference (MD) −5; 95%CI −7.75 to −2.25), and the itch severity score (ISS)7 (MD −2.15; 95% CI −3.2 to −1.1) does not increase (moderate certainty) quality of life (QoL) (Dermatology Life Quality Index (DLQI); MD −2.01; 95%CI −3.22 to −0.81) and decreases (moderate cer- tainty) rescue medication use (MD −1.68; 95%CI −2.95 to −0.4). Omalizumab 300 mg results in clinically meaningful improvements (moderate certainty) of the UAS7 (MD −11.05; 95%CI −12.87 to −9.24), the ISS7 (MD −4.45; 95%CI −5.39 to −3.51), and QoL (high certainty) (DLQI; MD −4.03; 95% CI −5.56 to −2.5) and decreases (moderate certainty) rescue medication use (MD −2.04; 95%CI −3.19 to −0.88) and drug-related serious AEs (RR 0.77; 95%CI 0.20 to 2.91).
(Last update: 12.2023)
Number of original publications in peer-reviewed journals: | 580 |
Number of reviews in peer-reviewed journals: | 210 |
Number of publications (original work and reviews) in peer-reviewed journals: | 790 |
Cumulative IF for original publications in peer-reviewed journals: | 4196.39 |
Cumulative IF for reviews in peer-reviewed journals: | 1409.32 |
Cumulative IF of publications (original work & reviews) in peer-reviewed journals: | 5605.71 |
Total number of citations: 36,836, h-index: 99 (Web of Science December 2023) | 36836 |
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