Publications

Publications, Books, Book Chapters and Reviews by Prof. Marcus Maurer, MD

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Eosinopenia, in Chronic Spontaneous Urticaria, Is Associated with High Disease Activity, Autoimmunity, and Poor Response to Treatment

Filename 372. Kolkhir et al., Eosinopenia CSU, JACIinPr2020.pdf
Filesize 915.50 KB
Version o.372
Date added June 5, 2020
Downloaded 5 times
Category Original Work
Authors Kolkhir, P., Church, M. K., Altrichter, S., Stahl Skov, P., Hawro, T., Frischbutter, S., Metz, M., and Maurer, M.
Citation Kolkhir, P., Church, M. K., Altrichter, S., Stahl Skov, P., Hawro, T., Frischbutter, S., Metz, M., and Maurer, M.: Eosinopenia, in chronic spontaneous urticaria, is associated with high disease activity, autoimmunity and poor response to treatment. J. Allergy Clin. Immunol. Pract. 2020: 8; 318-325.
Corresponding authors Maurer, M.
DocNum o.372
DocType PDF
Edition; Page 8; 318-325.
IF 8.86
Publisher J. Allergy Clin. Immunol. Pract.
ReleaseDate 2020

Background: Chronic spontaneous urticaria (CSU) is characterized by the degranulation of skin mast cells and the influx of basophils and eosinophils to affected skin sites. Blood basopenia has been linked to severe antihistamine-resistant CSU and type IIb autoimmunity, whereas the role of eosinophils in CSU is largely unknown.

Objective: To analyze data from 1613 patients with CSU from 2 centers to study the prevalence, role, and relevance of eosinopenia in CSU.

Methods: Peripheral blood eosinophil and basophil counts were measured by automated hematology analyzers. Patient files were screened for clinical characteristics, results of laboratory tests, the autologous serum skin test, the serum-induced basophil histamine release assay, and response to second-generation H1-antihistamines and omalizumab.

Results: Ten percent of patients with CSU had eosinopenia. Eosinopenia was associated with the female sex, high disease activity, autologous serum skin test and basophil histamine release assay positivity, low total IgE, and high levels of Creactive protein and IgG-antithyroperoxidase (P £ .007). Nonresponders to second-generation H1-antihistamines or omalizumab had significantly lower eosinophils as compared with responders (P < .05 and P < .01, respectively). Blood eosinophil counts correlated with basophil counts (r [ 0.396; P < .001), and 81% of patients with CSU with undetectable eosinophils had basopenia. The combination of eosinopenia and basopenia is a better predictor of nonresponse to secondgeneration H1-antihistamines than eosinopenia alone (odds ratio of 9.5 vs 4.8).

Conclusions: Eosinopenia in patients with CSU is associated with type IIb autoimmunity, high disease activity, and poor response to treatment. Eosinophils should be explored as biomarkers and investigated for their contribution to the pathogenesis of CSU.

 

(Last update: 12.2023)

Number of original publications in peer-reviewed journals:580
Number of reviews in peer-reviewed journals:210
Number of publications (original work and reviews) in peer-reviewed journals:790
Cumulative IF for original publications in peer-reviewed journals:4196.39
Cumulative IF for reviews in peer-reviewed journals:1409.32
Cumulative IF of publications (original work & reviews) in peer-reviewed journals:5605.71
Total number of citations: 36,836, h-index: 99 (Web of Science December 2023)36836

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