Publications

Publications, Books, Book Chapters and Reviews by Prof. Marcus Maurer, MD

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Flare size but not intensity reflects histamine-induced itch

Filename 406. Lehmann et al., Flare size ...itch, SkinPharmacolPhys 2020.pdf
Filesize 440 KB
Version o.406
Date added November 14, 2020
Downloaded 0 times
Category Original Work
Tags Axon reflex flare, capsaicin, cowhage, histamine, itch, Pruritus
Authors Lehmann, S., Deuring, E., Weller, K., Scheffel, J., Metz, M., Maurer, M., and Hawro, T.
Citation Lehmann, S., Deuring, E., Weller, K., Scheffel, J., Metz, M., Maurer, M., and Hawro, T.+: Flare size but not intensity reflects histamine-induced itch. Skin Pharmacol. Phys. 2020: 33; 244-252.
Corresponding authors Hawro, T.
DocNum o.406
DocType PDF
IF 3.48
Publisher Skin Pharmacol. Phys.
ReleaseDate 2020

Introduction: Flare reactions arise due to the release of vasodilators from sensory nerves caused by antidromic transmission of action potentials after the induction of itch.

Objective: We investigated the link between flare and itch using 3 models of itch.

Methods: Skin provocations with histamine, capsaicin, and cowhage were performed in 31 subjects. Itch was quantified using the visual analog scale. Flare was assessed using laser speckle contrast imaging (LSCI) and digital photography. Results: The duration, intensity, and area under the curve of histamine-induced itch correlated with the area of increased blood flow measured with LSCI (r = 0.545, p = 0.002; r = 0.575, p = 0.001; and r = 0.649, p < 0.001, respectively). Itch and skin blood flow in response to capsaicin or cowhage did not correlate.

Conclusion: In histamine-induced skin inflammation, itch and increased blood flow are linked. Thus, the area of histamine-induced flare may be used as a surrogate marker for histamine-induced itch.

(Last update: 08.2021)

Number of publications (original work and reviews) in peer-reviewed journals: 636
Number of original publications in peer-reviewed journals: 462
Number of reviews in peer-reviewed journals: 174
Cumulative IF of publications (original work & reviews) in peer-reviewed journals: 3834,12
Cumulative IF for original publications in peer-reviewed journals: 3043,14
Cumulative IF for reviews in peer-reviewed journals: 790,98
Citations, Hirsch index: (view on Web of Science) 26429