Publications
Publications, Books, Book Chapters and Reviews by Prof. Marcus Maurer, MD
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Galactose-α-1,3-Galactose Allergy Is Not a Hitherto Unrecognized Cause of Chronic Spontaneous Urticaria
Filename | 213. Maurer et al., Galactose, IAAI 2015.pdf |
Filesize | 78.29 KB |
Version | o.213 |
Date added | July 29, 2020 |
Downloaded | 0 times |
Category | Original Work |
Authors | Maurer, M. Church, M. K., Metz, M., Starkhammar, M., Hamsten, C., and van Hage, M. |
Citation | Maurer, M. Church, M. K., Metz, M., Starkhammar, M., Hamsten, C., and van Hage, M.: Galactose--1,3-galactose allergy is not a hitherto unrecognized cause of chronic spontaneous urticaria. Int. Arch. Allergy Immunol. 2015: 167; 250-252. |
Corresponding authors | Church, M. K. |
DocNum | O.213 |
DocType | |
Edition; Page | 167; 250-252 |
IF | 2.67 |
Publisher | Int. Arch. Allergy Immunol. |
ReleaseDate | 2015 |
Background: Tick bite-induced galactose-α-1,3-galactose (α-Gal) IgE and subsequent ingestion of red meat may cause delayed severe allergic reactions including urticaria, gastrointestinal symptoms or anaphylaxis. We tested the hypothesis that increased levels of IgE to α-Gal due to tick bites and the subsequent ingestion of red meat or meat products may possibly be an un(der)recognized cause of chronic spontaneous urticaria (CSU).
Methods: Levels of IgE to α-Gal and total IgE were measured (ImmunoCAP, Phadia AB/Thermo Fisher Scientific) in 83 patients (61 female and 22 male, median age 43 years, range 18–82) from the Department of Dermatology and Allergy, Charité – Universitätsmedizin, Berlin, Germany. All had been clinically diagnosed with moderate-to-severe CSU of a median duration of 2.9 years (range 0.1–50).
Results: Eighty of the 83 patients (96%) had undetectable (<0.1 kU A /l) serum levels of IgE against α-Gal. The levels in the remaining 3 were all low (0.25, 0.4 and 3.1 kU A /l). In no patient, including those with measurable serum levels of IgE against α-Gal, was eating red meat associated with the development of symptoms of urticaria. Conclusion: Our results indicate that an allergic response to α-Gal is highly unlikely to be a hitherto unrecognized common cause of CSU.
(Last update: 12.2023)
Number of original publications in peer-reviewed journals: | 580 |
Number of reviews in peer-reviewed journals: | 210 |
Number of publications (original work and reviews) in peer-reviewed journals: | 790 |
Cumulative IF for original publications in peer-reviewed journals: | 4196.39 |
Cumulative IF for reviews in peer-reviewed journals: | 1409.32 |
Cumulative IF of publications (original work & reviews) in peer-reviewed journals: | 5605.71 |
Total number of citations: 36,836, h-index: 99 (Web of Science December 2023) | 36836 |
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